P148 ANTHROPOMETRIC MEASURES IN INTERMITTENT CLAUDICATION AND CRITICAL LIMB ISCHEMIA

Joana Ferreira; Jacinta Campos

doi:10.1016/j.artres.2018.10.201

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Volume 24, Issue C, December 2018, Pages 122 - 122

P148 ANTHROPOMETRIC MEASURES IN INTERMITTENT CLAUDICATION AND CRITICAL LIMB ISCHEMIA

Authors

Joana Ferreira¹, Jacinta Campos²

¹Hospital da Senhora da Oliveira Guimarães, Portugal

²Centro Hospital Gaia/Espinho, Portugal

Available Online 4 December 2018.

DOI: 10.1016/j.artres.2018.10.201 How to use a DOI?
Abstract: Purpose/Background/Objective: Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis and obesity is one of its well-established risk factors 1–5. PAD is classified in intermittent claudication (IC) and critical limb ischemia (CLI), according to the its severity6. Therefore, we hypothesized that anthropometric measures of adiposity will be associated with the severity of PAD.

Methods: We studied prospectively 46 males who underwent aorto-bifemoral bypass from 2013 to 2016: The body mass index (BMI), the waist circumference, the waist-to-hip ratio and the ankle-brachial index (ABI) were determined.

Results: 17 IC: 60.69 ± 7.46 years old; 17.6% with diabetes; 70% with hypertension and 100% were smoker/ex-smoker. 29 CLI: 64.51 ± 8.42 years old; 44.82% with diabetes; 51.72% with hypertension and 86.2% were smoker/ex-smoker. All the anthropometric measures were higher in the IC group (BMI:25.10 ± 5.01 Kg/m² versus 23.52 ± 3.59 Kg/m², p = 0.27; weight: 72.74 ± 9.84 Kg versus 65.92 ± 10.89 Kg p = 0.043; waist circumference: 98.65 ± 8.19 cm versus 89.38 ± 15.91 cm p = 0.017; waist-to-hip ratio: 1.06 ± 0.06 versus 1.01 ± 0.06 p = 0.038). No relationship was found between ABI and the anthropometric measures.

Conclusion: This is the first study of anthropometric measures in IC and CLI patients undergoing aorto-bifemoral bypass. Adipose tissue was not directly determined in this study, but the measurements used have been shown to correlate well with adiposity. We found an inverse relationship between body fat content and the severity of PAD. Patients with CLI had a lower weight, waist circumference and waist-to-hip ratio, and these differences were statistically significant. Obesity is a risk factor for atherosclerosis, but as PAD progresses to CLI, there is an increase in tissue hypoxia, which causes an inflammatory environment promoting proteolysis and lipolysis.
Open Access: This is an open access article distributed under the CC BY-NC license.

References

1.MJ Ferreira, P Barroso, and N Duarte, Doença arterial periférica, Rev Port Clin Geral, Vol. 26, 2010, pp. 502-9.

2.P Alexandersen, LB Tankó, YZ Bagger, et al., Associations between aortic calcification and components of body composition in elderly Men, Obesity, Vol. 14, No. 9, 2006, pp. 1571-8.

3.WM Freitas, LSF Carvalho, FA Moura, and AC Sposito, Atherosclerotic disease in octogenarians: A challenge for science and clinical practice, Atherosclerosis, Vol. 225, No. 2, Dec 2012, pp. 281-9.

4.I Akoumianakis and C Antoniades, The interplay between adipose tissue and the cardiovascular system: is fat always bad?, Cardiovasc Res., Vol. 113, No. 9, 1 Jul 2017, pp. 999-1008.

5.WB Lau, K Ohashi, Y Wang, H Ogawa, T Murohara, et al., Role of adipokines in cardiovascular disease, Circ J., Vol. 81, No. 7, pp. 920 928.

6.C Fox, J Massaro, CL Schlett, SJ Lehmann, JB Meigs, CJ O’Donnell, et al., Periaortic fat deposition is associated with peripheral arterial disease - The Framingham heart study, Circ Cardiovasc Imaging, Vol. 3, No. 5, Sep 2010, pp. 515-9.

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Journal: Artery Research
Volume-Issue: 24 - C
Pages: 122 - 122
Publication Date: 2018/12/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.10.201 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Joana Ferreira
AU  - Jacinta Campos
PY  - 2018
DA  - 2018/12/04
TI  - P148 ANTHROPOMETRIC MEASURES IN INTERMITTENT CLAUDICATION AND CRITICAL LIMB ISCHEMIA
JO  - Artery Research
SP  - 122
EP  - 122
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.201
DO  - 10.1016/j.artres.2018.10.201
ID  - Ferreira2018
ER  -

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