P149 LOW CAROTID ARTERIAL STIFFNESS IN YOUNG TYPE1 DIABETIC PATIENTS COMPARED WITH AGE-MATCHED CONTROLS

Alessandro Giudici; Carlo Palombo; Carmela Morizzo; Michaela Kozakova; Lorenzo Losso; Kennedy J. Cruickshank; Ashraf W. Khir

doi:10.1016/j.artres.2018.10.202

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Volume 24, Issue C, December 2018, Pages 123 - 123

P149 LOW CAROTID ARTERIAL STIFFNESS IN YOUNG TYPE1 DIABETIC PATIENTS COMPARED WITH AGE-MATCHED CONTROLS

Authors

Alessandro Giudici¹, Carlo Palombo², Carmela Morizzo², Michaela Kozakova², Lorenzo Losso², Kennedy J. Cruickshank³, Ashraf W. Khir¹

¹Brunel University London, Uxbridge, UK

²University of Pisa, Medical School, Pisa, Italy

³Cardiovascular Medicine Group, Diabetes & Nutritional Sciences Division, King’s College London, London, UK

Available Online 4 December 2018.

DOI: 10.1016/j.artres.2018.10.202 How to use a DOI?
Abstract: Background: Local pulse wave velocity (c) is widely used as an index of local carotid arterial stiffness. In middle-aged type1 and type2 diabetic patients, arterial stiffness is higher than in healthy people, but much less data are available for young subjects. Our aim was to quantify the changes in c associated with ageing and type1 diabetes in young patients.

Methods: Pressure and diameter waveforms of healthy control (n = 53, 29 male, mean age 39 ± 17) and type1 diabetic (n = 20, 15 male, mean age 19 ± 2.5) subjects have been acquired simultaneously using tonometry (500 or 1000Hz) and an ultrasound probe (1kHz) at the level of the left and right common carotid artery, respectively. The geometrical similarity between the right and left common carotid artery was verified, and the two signals were assumed as recorded at the same site. The PD2-loop method [1] was used to calculate c in late diastole as follow: c = D0dPρ d(D2).

Results: In controls, c remained approximately constant up to ages 35–44y, at ±4 m/s. From 45–54 years old, c increased up to 7m/s in elderly subjects (figure1-left). In young diabetic subjects (15–24), c was lower than in aged-matched control subjects (mean ±95% C.I., diabetic 3.51 ± 0.007 and control 3.78 ± 0.005, p < 0.05) (figure1-right).

Conclusions: Local stiffness increases with age in the human carotid artery. As found for the descending thoracic aorta previously^[2], younger T1 diabetic patients may have more compliant vessels initially, aggravating their tendency to stiffen later.
Open Access: This is an open access article distributed under the CC BY-NC license.

References

1.J Alastruey, “Numerical assessment of time-domain Methods: for the estimation of local arterial pulse wave speed”, Journal of Biomechanics, Vol. 44, 2011, pp. 885-891.

2.ED Lehmann, RG Gosling, and PH Sönksen, “Arterial wall compliance in diabetes”, Diabetic Medicine, Vol. 9, No. 2, 1992, pp. 114-119.

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Journal: Artery Research
Volume-Issue: 24 - C
Pages: 123 - 123
Publication Date: 2018/12/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.10.202 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Alessandro Giudici
AU  - Carlo Palombo
AU  - Carmela Morizzo
AU  - Michaela Kozakova
AU  - Lorenzo Losso
AU  - Kennedy J. Cruickshank
AU  - Ashraf W. Khir
PY  - 2018
DA  - 2018/12/04
TI  - P149 LOW CAROTID ARTERIAL STIFFNESS IN YOUNG TYPE1 DIABETIC PATIENTS COMPARED WITH AGE-MATCHED CONTROLS
JO  - Artery Research
SP  - 123
EP  - 123
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.202
DO  - 10.1016/j.artres.2018.10.202
ID  - Giudici2018
ER  -

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