Artery Research

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Volume 24, Issue C, December 2018, Pages 125 - 125

P156 CARDIO ANKLE VASCULAR INDEX (CAVI) AS ARTERIAL STIFFNESS MARKER IN SUBJECTS WITH ANKYLOSING SPONDYLITIS

Authors
Guillermo Alanis-Sánchez1, Ernesto Cardona-Muñoz2, David Cardona-Müller3, Sylvia Totsuka-Sutto3, Oscar Mares-Flores2, César Murguia-Soto2, Diego Castañeda-Zaragoza4, David Montes-Martínez5, Carlos Ramos-Becerra6
1MSc Student, West Lab ICORD, University of British Columbia, USA
2Arterial Stiffness Laboratory, Department of Physiology, University of Guadalajara, USA
3Arterial Stiffness Laboratory, Department of Physiology, University of Guadalajara, Mexico, USA
4Arterial Stiffness Laboratory, University of Guadalajara, Mexicio, USA
5Arterial Stiffness Laboratory, Department of Physiology, University of Guadalajara, Mexico, USA
6University of Guadalajara, Department of Physiology, Arterial Stiffness, USA
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.209How to use a DOI?
Abstract

Background: Ankylosing spondylitis (AS) is a chronic, inflammatory disease of the axial spine that can manifest with various clinical signs and symptoms1.Cardio-ankle vascular index (CAVI), which is calculated based on the stiffness parameter thus obtained, is theoretically independent of changes in blood pressure. With this distinct advantage, CAVI has been widely applied clinically to assess arterial stiffness in subjects with or without known cardiovascular diseases2.

Objectives: The aim of this study was to evaluate the Cardio Ankle Vascular Index (CAVI) in subjects with ankylosing spondylitis pared with controls free of morbidities.

Methods: We enrolled 41 participants in this study. Eighteen patients with diagnosed AS and 23 controls free of comorbidities. CAVI was measured by VaSera VS-1000 (Fukuda- Denshi Company, Ltd, Tokyo, Japan).

Results: The results are expressed as mean ± standard deviation for continuous variables. The data were analyzed using SPSS v. 24 (SPSS Inc., Chicago, IL). The normality of the data was evaluated with Shapiro-Wilk test. A two-tailed p < 0.05 was considered statistically significant. Individuals with AS exhibited greater pSBP (p < 0.01), DBP (p < 0.05), and MBP (p < 0.01) compared to controls. Moreover, in the AS group we observed a higher CAVI with a mean difference of 1.14 (p < 0.01, 95% CI of .41 to 1.8) (Figure 1).

Conclusion: AS is a chronic inflammatory disease that primarily affects the articular joints of the spine. Individuals with ankylosing spondylitis showed increased CAVI, this contributes to explain the higher risk of cardiovascular disease in this pathological condition.

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This is an open access article distributed under the CC BY-NC license.

References

1.D Van der Heijde, S Ramiro, R Landewé, et al., 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis, Ann Rheum Dis, Vol. 76, 2017, pp. 978-91.
2.K Shirai, J Utino, K Otsuka, and M Takata, A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI), J Atheroscler Thromb., Vol. 13, No. 2, 2006, pp. 101-107.
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Journal
Artery Research
Volume-Issue
24 - C
Pages
125 - 125
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.209How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Guillermo Alanis-Sánchez
AU  - Ernesto Cardona-Muñoz
AU  - David Cardona-Müller
AU  - Sylvia Totsuka-Sutto
AU  - Oscar Mares-Flores
AU  - César Murguia-Soto
AU  - Diego Castañeda-Zaragoza
AU  - David Montes-Martínez
AU  - Carlos Ramos-Becerra
PY  - 2018
DA  - 2018/12/04
TI  - P156 CARDIO ANKLE VASCULAR INDEX (CAVI) AS ARTERIAL STIFFNESS MARKER IN SUBJECTS WITH ANKYLOSING SPONDYLITIS
JO  - Artery Research
SP  - 125
EP  - 125
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.209
DO  - 10.1016/j.artres.2018.10.209
ID  - Alanis-Sánchez2018
ER  -