Artery Research

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Volume 24, Issue C, December 2018, Pages 120 - 120

P140 ARTERIAL WAVE DYNAMICS IN THE HORSE: INSIGHTS OBTAINED FROM A 1D ARTERIAL NETWORK MODEL SIMULATION

Authors
Daimé Campos Arias1, 2, Lisse Vera3, Sofie Muylle4, Nikos Stergiopulos5, Gunther van Loon3, Patrick Segers1
1Ghent University, IBiTech-bioMMeda, Ghent, Belgium
2Cujae, Cemat, BioMec, Havana, Cuba, Belgium
3Ghent University, Dept. of Large Animal Internal Medicine, Ghent, Belgium
4Ghent University, Dept. of Morphology, Ghent, Belgium
5LHTC, EPFL, Lausanne, Switzerland
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.193How to use a DOI?
Abstract

Background: Relatively little is known about equine arterial hemodynamics because it is technically and ethically challenging to investigate a large number of arteries. Pulsed-wave Doppler images of arterial flow velocities typically display patterns of a higher oscillatory nature than in humans, but the background of these oscillations is not well understood. The aim of this study is to gain insight into equine arterial hemodynamics and physiology through 1D arterial network simulations.

Methods: Anatomical data of lengths, diameters and branching angles collected post-mortem from five horses, were used as the input for a previously validated (in humans) 1D arterial network model [1]. Cardiac and arterial parameters were tuned to equine physiology at rest (heart rate 40 bpm, cardiac output 36 l/min, mean arterial pressure 92 mmHg). Pressure and flow waveforms were simulated for the ascending aorta, right common carotid and median (in the front limbs) arteries. Simulated flow velocities were compared with ultrasound data from one horse and wave intensity analysis (WIA) was used to study wave dynamics.

Results: Figure 1 shows that simulated flow velocities are quantitatively close to ultrasound data. Ultrasound images show a high level of oscillations, also present in the simulations. The most prominent feature revealed by WIA is the existence of a mid-systolic forward expansion wave and prominent wave activity throughout diastole.

Conclusions: Initial model simulations indicate a great activity of wave reflection and a quantitative match of intra-arterial waveforms with ultrasound data. Simulations are also able to capture the oscillatory patterns observed in ultrasound data.

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This is an open access article distributed under the CC BY-NC license.

References

1.P Reymond, F Merenda, F Perren, D Rüfenacht, and N Stergiopulos, Validation of a one-dimensional model of the systemic arterial tree, Am J Physiol Heart Circ Physiol, Vol. 297, No. 1, 2009, pp. H208-H22.
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Journal
Artery Research
Volume-Issue
24 - C
Pages
120 - 120
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.193How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Daimé Campos Arias
AU  - Lisse Vera
AU  - Sofie Muylle
AU  - Nikos Stergiopulos
AU  - Gunther van Loon
AU  - Patrick Segers
PY  - 2018
DA  - 2018/12/04
TI  - P140 ARTERIAL WAVE DYNAMICS IN THE HORSE: INSIGHTS OBTAINED FROM A 1D ARTERIAL NETWORK MODEL SIMULATION
JO  - Artery Research
SP  - 120
EP  - 120
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.193
DO  - 10.1016/j.artres.2018.10.193
ID  - CamposArias2018
ER  -