P141 TELOMERE DYNAMICS RELATION WITH OBESITY

Simon Toupance; Mirna Chahine; Irini Tzanetakou; Carlos Labat; Sylvie Gautier; Cécilé Lakomy; Pascal Rossi; Toufic Moussallem; Pierre Yared; Didier Quilliot; Evangelos Menenakos; Roland Asmar; Athanase Benetos

doi:10.1016/j.artres.2018.10.194

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Volume 24, Issue C, December 2018, Pages 120 - 120

P141 TELOMERE DYNAMICS RELATION WITH OBESITY

Authors

Simon Toupance¹, Mirna Chahine², Irini Tzanetakou³, Carlos Labat⁴, Sylvie Gautier¹, Cécilé Lakomy⁴, Pascal Rossi⁵, Toufic Moussallem⁶, Pierre Yared⁶, Didier Quilliot⁷, Evangelos Menenakos⁸, Roland Asmar², Athanase Benetos¹^{, 4}

¹Department of Geriatrics, University Hospital of Nancy, Nancy, France

²Foundation-Medical Research Institutes, Beirut, Lebanon

³European University of Cyprus, School of Sciences, Engomi, Cyprus

⁴Inserm UMRS 1116, University of Lorraine, Nancy, France

⁵North hospital, APHM, Marseille, France

⁶Faculty of Medical Sciences, Lebanese University, Hadath, Lebanon

⁷Department of Endocrinolgy, University Hospital of Nancy, Nancy, France

⁸Medical School of Athens, National and Kapodistrian University of Athens, Greece

Available Online 4 December 2018.

DOI: 10.1016/j.artres.2018.10.194 How to use a DOI?
Abstract: Background: The relation between telomere dynamics and obesity remains unclear. Cross-sectional studies found associations between short leukocyte telomere length (LTL) and high body mass index (BMI) but longitudinal studies did not find any association between LTL attrition and BMI. In two parallel studies, we aimed to assess the relationship between obesity and telomere dynamics in different tissues.

Methods: Study 1: Measurements of LTL and TL in skeletal muscle (MTL) were performed in 53 subjects with severe obesity (BMI > 35) and in 53 age- and sex-matched without obesity (21 < BMI < 30). MTL is a proxy of TL at birth and the LTL/MTL ratio represents life-long telomere attrition. Study 2: Measurements of TL in subcutaneous fat (SCF), a high proliferative adipose tissue, and visceral fat (VF), a low proliferative one in 50 severe obese bariatric patients. TL measurements were performed by Southern blot.

Results: Study 1: In younger (<55 years), but not in older, LTL and LTL/MTL were shorter in obese patients vs controls (7.16 kb vs 7.54 kb, p < 0.05 for LTL and 81% vs 84%, p < 0.05 for LTL/MTL). Study 2: Within obese bariatric patients, SCF/VF TL ratio was lower in those with early onset obesity (96% for obesity since childhood vs 97% since adolescence vs 100% for adult development of obesity; p < 0.05).

Conclusions: Early life obesity is associated with higher TL attrition leading to shorter TL in high proliferative tissues.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 24 - C
Pages: 120 - 120
Publication Date: 2018/12/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.10.194 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Simon Toupance
AU  - Mirna Chahine
AU  - Irini Tzanetakou
AU  - Carlos Labat
AU  - Sylvie Gautier
AU  - Cécilé Lakomy
AU  - Pascal Rossi
AU  - Toufic Moussallem
AU  - Pierre Yared
AU  - Didier Quilliot
AU  - Evangelos Menenakos
AU  - Roland Asmar
AU  - Athanase Benetos
PY  - 2018
DA  - 2018/12/04
TI  - P141 TELOMERE DYNAMICS RELATION WITH OBESITY
JO  - Artery Research
SP  - 120
EP  - 120
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.194
DO  - 10.1016/j.artres.2018.10.194
ID  - Toupance2018
ER  -

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