Artery Research

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Volume 24, Issue C, December 2018, Pages 116 - 116

P127 SPATIAL VARIATION OF RESERVOIR PRESSURE IN CHILDREN ASSESSED WITH HIGH FIDELITY PRESSURE MEASUREMENT IN FIVE AORTIC LOCATIONS

Authors
Jonathan Mynard1, 2, 3, Lucas Eastaugh4, 5, Geoff Lane5, Greta Goldsmith4, Gabriella Springall4, Alberto Avolio6, Joe Smolich4, 2, Michael Cheung4, 2, 5
1Murdoch Children’s Research Institute, Parkville, VIC, Australia
2University of Melbourne, Parkville, VIC, Australia
3Royal Children’s Hospital, Parkville, VIC, Australia
4Murdoch Childrens Research Institute, Parkville, VIC, Australia
5Royal Children’s Hospital, Parkville, VIC, Australia
6Macquarie University, Sydney, NSW, Australia
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.180How to use a DOI?
Abstract

Objective: To assess whether reservoir pressure (Pres) in young individuals with a compliant aorta is uniform throughout the aorta, as has recently been reported in older adults with cardiovascular disease (1).

Methods: High fidelity pressure was measured with a Verrata wire (Philips Volcano) in 5 aortic locations (ascending-to-abdominal) via pull-back in 11 children with a normal aorta (age 10.4 ± 4.9 years, mean ± SD). Pres was calculated using the ‘pressure-only’ approach (2), with exponential fitting over the whole of diastole (1) (WholeDia) or the period when pressure declined in an approximately exponential fashion (ExpDia).

Results: ExpDia produced a better fit than WholeDia (R2=0.99 ± 0.01 vs 0.91 ± 0.11, P < 0.001). Pres amplitude (ΔPres) in the ascending aorta from WholeDia fitting (12.0 ± 4.1 mmHg) was less than with ExpDia fitting (19.0 ± 5.2, P = 0.001). The zero-flow asymptotic pressure (Pinf) obtained from the fitting procedure was negative (non-physiological) in 76% (WholeDia) and 44% (ExpDia) of recordings, but fixing Pinf to 37 mmHg (average of physiological values) had little effect on the resulting ΔPres. ΔPres varied by 5.7 ± 3.0 mmHg (WholeDia) and 7.3 ± 3.7 mmHg (ExpDia) between aortic locations (both P<0.001 compared with zero), corresponding to 44% ± 30% and 38% ± 17% of average ΔPres respectively. Maximum instantaneous spatial differences in Pres amounted to a substantial percentage of ΔPres (45% ± 37% WholeDia; 24% ± 26% ExpDia) and were not reduced by time and/or pressure offsets to align Pres foot.

Conclusion: In young individuals, Pres was sensitive to the fitting period and often resulted in non-physiological Pinf values. Regardless of calculation method or alignment, Pres was not uniform along the aorta.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
24 - C
Pages
116 - 116
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.180How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Jonathan Mynard
AU  - Lucas Eastaugh
AU  - Geoff Lane
AU  - Greta Goldsmith
AU  - Gabriella Springall
AU  - Alberto Avolio
AU  - Joe Smolich
AU  - Michael Cheung
PY  - 2018
DA  - 2018/12/04
TI  - P127 SPATIAL VARIATION OF RESERVOIR PRESSURE IN CHILDREN ASSESSED WITH HIGH FIDELITY PRESSURE MEASUREMENT IN FIVE AORTIC LOCATIONS
JO  - Artery Research
SP  - 116
EP  - 116
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.180
DO  - 10.1016/j.artres.2018.10.180
ID  - Mynard2018
ER  -