P127 SPATIAL VARIATION OF RESERVOIR PRESSURE IN CHILDREN ASSESSED WITH HIGH FIDELITY PRESSURE MEASUREMENT IN FIVE AORTIC LOCATIONS

Jonathan Mynard; Lucas Eastaugh; Geoff Lane; Greta Goldsmith; Gabriella Springall; Alberto Avolio; Joe Smolich; Michael Cheung

doi:10.1016/j.artres.2018.10.180

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Volume 24, Issue C, December 2018, Pages 116 - 116

P127 SPATIAL VARIATION OF RESERVOIR PRESSURE IN CHILDREN ASSESSED WITH HIGH FIDELITY PRESSURE MEASUREMENT IN FIVE AORTIC LOCATIONS

Authors

Jonathan Mynard¹^{, 2}^{, 3}, Lucas Eastaugh⁴^{, 5}, Geoff Lane⁵, Greta Goldsmith⁴, Gabriella Springall⁴, Alberto Avolio⁶, Joe Smolich⁴^{, 2}, Michael Cheung⁴^{, 2}^{, 5}

¹Murdoch Children’s Research Institute, Parkville, VIC, Australia

²University of Melbourne, Parkville, VIC, Australia

³Royal Children’s Hospital, Parkville, VIC, Australia

⁴Murdoch Childrens Research Institute, Parkville, VIC, Australia

⁵Royal Children’s Hospital, Parkville, VIC, Australia

⁶Macquarie University, Sydney, NSW, Australia

Available Online 4 December 2018.

DOI: 10.1016/j.artres.2018.10.180 How to use a DOI?
Abstract: Objective: To assess whether reservoir pressure (Pres) in young individuals with a compliant aorta is uniform throughout the aorta, as has recently been reported in older adults with cardiovascular disease (1).

Methods: High fidelity pressure was measured with a Verrata wire (Philips Volcano) in 5 aortic locations (ascending-to-abdominal) via pull-back in 11 children with a normal aorta (age 10.4 ± 4.9 years, mean ± SD). Pres was calculated using the ‘pressure-only’ approach (2), with exponential fitting over the whole of diastole (1) (WholeDia) or the period when pressure declined in an approximately exponential fashion (ExpDia).

Results: ExpDia produced a better fit than WholeDia (R2=0.99 ± 0.01 vs 0.91 ± 0.11, P < 0.001). P_res amplitude (ΔP_res) in the ascending aorta from WholeDia fitting (12.0 ± 4.1 mmHg) was less than with ExpDia fitting (19.0 ± 5.2, P = 0.001). The zero-flow asymptotic pressure (P_inf) obtained from the fitting procedure was negative (non-physiological) in 76% (WholeDia) and 44% (ExpDia) of recordings, but fixing P_inf to 37 mmHg (average of physiological values) had little effect on the resulting ΔP_res. ΔP_res varied by 5.7 ± 3.0 mmHg (WholeDia) and 7.3 ± 3.7 mmHg (ExpDia) between aortic locations (both P<0.001 compared with zero), corresponding to 44% ± 30% and 38% ± 17% of average ΔP_res respectively. Maximum instantaneous spatial differences in P_res amounted to a substantial percentage of ΔP_res (45% ± 37% WholeDia; 24% ± 26% ExpDia) and were not reduced by time and/or pressure offsets to align P_res foot.

Conclusion: In young individuals, P_res was sensitive to the fitting period and often resulted in non-physiological P_inf values. Regardless of calculation method or alignment, P_res was not uniform along the aorta.
Open Access: This is an open access article distributed under the CC BY-NC license.

References

1.O Narayan, KH Parker, JE Davies, AD Hughes, IT Meredith, and JD Cameron, Reservoir pressure analysis of aortic blood pressure: an in-vivo study at five locations in humans, J Hypertens, Vol. 35, No. 10, 2017, pp. 2025-33.

2.J Aguado-Sierra, J Alastruey, JJ Wang, N Hadjiloizou, J Davies, and KH Parker, Separation of the reservoir and wave pressure and velocity from measurements at an arbitrary location in arteries, Proc Inst Mech Eng [H]., Vol. 222, No. 4, 2008, pp. 403-16.

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Journal: Artery Research
Volume-Issue: 24 - C
Pages: 116 - 116
Publication Date: 2018/12/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.10.180 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Jonathan Mynard
AU  - Lucas Eastaugh
AU  - Geoff Lane
AU  - Greta Goldsmith
AU  - Gabriella Springall
AU  - Alberto Avolio
AU  - Joe Smolich
AU  - Michael Cheung
PY  - 2018
DA  - 2018/12/04
TI  - P127 SPATIAL VARIATION OF RESERVOIR PRESSURE IN CHILDREN ASSESSED WITH HIGH FIDELITY PRESSURE MEASUREMENT IN FIVE AORTIC LOCATIONS
JO  - Artery Research
SP  - 116
EP  - 116
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.180
DO  - 10.1016/j.artres.2018.10.180
ID  - Mynard2018
ER  -

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