P98 AGE AND GENDER DIFFERENCES IN VARIABILITY OF WAVE REFLECTIONS OVER 24 HOURS: THE INTERNATIONAL 24-HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)

DOI

10.1016/j.artres.2018.10.151How to use a DOI?

Abstract

Background: Wave reflection parameters predict cardiovascular events, but 24-hour profiles in large samples of healthy adults are unknown.

Methods: In 1645 individuals free from antihypertensive drugs from 11 centers in Europe and Asia, 24-hour blood pressure monitoring with a validated oscillometric brachial cuff (Mobilograph, I.E.M., Stolberg; Germany) was performed. Brachial waveforms were acquired and processed with ARCSolver algorithms to derive information relating to wave reflections using pulse waveform analysis (heart-rate corrected augmentation index-AIx75, augmentation pressure-AP) and wave separation analysis (backward wave amplitude-Pb, reflection magnitude-RM). Nighttime/daytime difference (N/D) was nighttime (01.00–06.00) minus daytime (09.00–21.00) values/daytime values. Participants were categorized as young (13–39 years; male/female: 219/112), middle-aged (40–66 years; male/female: 545/553), and old (67–104 years; male/female: 86/130).

Results: 24-hour measures of wave reflections increased with increasing age and were significantly lower in men compared to women (AIx75: 18.3 vs 28.0 %, AP: 10.1 vs 14.9 mm Hg, Pb: 18.9 vs 20.0 mm Hg, RM: 63.0 vs 66.2). AIx75 was higher during daytime compared to nighttime (23.3 vs 21.3%), but only in young and middle-aged participants. For all participants, AP (11.6 vs 14.5 mm Hg), Pb (18.5 vs 21.7 mm Hg), and RM (62.9 vs 68.8) were higher during nighttime compared to daytime. N/D varied with age and was more pronounced in younger individuals.

Conclusion: 24-hour variability of wave reflection parameters differs according to age and gender. In future, this information could be useful for tailoring individual cardiovascular risk management.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Thomas Weber
AU  - Siegfired Wasserheurer
AU  - James Sharman
AU  - Cristina Giannatasio
AU  - Piotr Jankowski
AU  - Yan Li
AU  - Alessandro Maloberti
AU  - Barry Mcdonnell
AU  - Carmel McEniery
AU  - Maria Lorenza Muisan
AU  - Janos Nemcsik
AU  - Anna Paini
AU  - Enrique Rodilla
AU  - Ian Wilkinson
AU  - Robert Zweiker
AU  - Athanase Protogerou
PY  - 2018
DA  - 2018/12/04
TI  - P98 AGE AND GENDER DIFFERENCES IN VARIABILITY OF WAVE REFLECTIONS OVER 24 HOURS: THE INTERNATIONAL 24-HOUR AMBULATORY AORTIC BLOOD PRESSURE CONSORTIUM (I24ABC)
JO  - Artery Research
SP  - 107
EP  - 107
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.151
DO  - 10.1016/j.artres.2018.10.151
ID  - Weber2018
ER  -