Artery Research

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Volume 24, Issue C, December 2018, Pages 107 - 107

P97 FAMILY PATTERNS OF CENTRAL HAEMODYNAMICS ACROSS THREE GENERATIONS IN THE MALMö OFFSPRING STUDY

Authors
Peter Nilsson1, Erik Petersson Rosberg2
1Lund University, Department of Clinical Sciences, Skane University Hospital, Jan Waldenstroms gata 15, Level 5, S-20502, Malmö, Sweden
2Lund University, Department of Clinical Sciences, Skane University Hospital, Malmö, Sweden
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.150How to use a DOI?
Abstract

Background: Markers of central haemodynamics have in recent years emerged as promising predictors of cardiovascular disease (CVD). Central haemodynamics are affected early in the development of vascular aging and affect organs directly attached to large arteries. Carotid-Femoral pulse wave velocity (c-f PWV), Augmentation index (Aix), and central systolic blood pressure (cSBP) are variables from indirect measurements that reflect central haemodynamic and arterial stiffness. Family patterns exist [1].

Aim: To investigate if a relationship exists for patterns of central haemodynamics across three related generations, especially c-f PWV.

Methods: In all, 1131 participants from Malmö Diet Cancer Study (MDCS) and Malmö Offspring Study (MOS) were included in this study. c-f PWV was measured in grandparents and in all offspring. Correlation analyses of c-f PWV between offspring and c-f PWV in parents and grandparents were conducted. Parents and grandparents were divided in quartiles by c-f PWV and offspring c-f PWV, and cSBP means were compared with one-way ANOVA analyses. Multiple regression analyses were conducted to adjust for age, sex, BMI, SBP and fasting glucose.

Results: c-f PWV in grandchildren was positively correlated with c-f PWV in parents (r = 0.26, p < 0.001) and in grandparents (r = 0.29, p < 0.001). Offspring c-f PWV correlated significantly with parental Aix and cSBP. Parents with high c-f PWV had offspring with statistically significant higher means of c-f PWV and cSBP than parents with low c-f PWV.

Conclusion: Measures of central haemodynamic are positively correlated across three generations in a population-based study.

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This is an open access article distributed under the CC BY-NC license.

References

1.AA Fatehali, M Gottsäter, and PM Nilsson, Family history of cardiometabolic diseases and its association with arterial stiffness in the Malmö Diet Cancer cohort, J Hypertens, Vol. 35, No. 11, Nov 2017, pp. 2262-2267.
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Journal
Artery Research
Volume-Issue
24 - C
Pages
107 - 107
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.150How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Peter Nilsson
AU  - Erik Petersson Rosberg
PY  - 2018
DA  - 2018/12/04
TI  - P97 FAMILY PATTERNS OF CENTRAL HAEMODYNAMICS ACROSS THREE GENERATIONS IN THE MALMö OFFSPRING STUDY
JO  - Artery Research
SP  - 107
EP  - 107
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.150
DO  - 10.1016/j.artres.2018.10.150
ID  - Nilsson2018
ER  -