Artery Research

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Volume 24, Issue C, December 2018, Pages 92 - 92

P49 QUANTIFYING WAVE REFLECTION IN CHILDREN: INVASIVE VS NON-INVASIVE CENTRAL AUGMENTATION INDEX AND REFLECTION MAGNITUDE AND THEIR ASSOCIATION WITH LEFT VENTRICULAR MASS

Authors
Jonathan Mynard1, 2, 3, Greta Goldsmith1, Remi Kowalski4, 2, 5, Lucas Eastaugh4, 5, Geoff Lane5, Gabriella Springall4, Joe Smolich4, 2, Alberto Avolio6, Michael Cheung4, 2, 5
1Murdoch Children’s Research Institute, Parkville, VIC, Australia
2University of Melbourne, Parkville, VIC, Australia
3Royal Children’s Hospital, University of Melbourne, Parkville, VIC, Australia
4Murdoch Childrens Research Institute, Parkville, VIC, Australia
5Royal Children’s Hospital, Parkville, VIC, Australia
6Macquarie University, Sydney, NSW, Australia
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.102How to use a DOI?
Abstract

Objective: The aims of this study in children were to 1) evaluate two brachial oscillometric devices for estimating central augmentation index (AIx) and reflection magnitude (RM), and 2) test whether AIx or RM are associated with left ventricular mass index (LVMI).

Methods: Intra-aortic (IA) AIx was calculated from high-fidelity pressure measured with a Verrata wire (Philips Volcano) in 60 children (9.2 ± 4.7 years) with unobstructed aorta undergoing clinically-indicated catheterisation. AIx was also obtained from SphygmoCor XCEL (SC, AtCor) and/or Mobil-o-Graph (MB, IEM) brachial oscillometric devices. RM(IA) was calculated via wave separation using a representative normalised flow waveform obtained from MRI in a separate group of normal adolescents, RM(SC) via the triangulation method, and RM(MB) provided by the proprietary software. LVMI was estimated via echocardiography.

Results: Invasive vs non-invasive AIx and RM are compared in the Table. AIx(IA) correlated weakly with AIx(SC) (R = 0.27, P = 0.04) but not AIx(MB) (P = 0.4). Neither RM(SC) nor RM(MB) correlated with RM(IA) (P = 0.13 and P = 0.96 respectively). RM(IA) was moderately correlated with AIx(IA) (R = 0.69, P < 0.001) and weakly correlated with AIx(SC) (R = 0.36, P = 0.007) but not AIx(MB) (P = 0.7). In a multivariable regression, height (P < 0.001) and RM (IA) (P = 0.04) were independently and positively associated with LVMI (adjusted R2 = 0.24), whereas there were no associations of any AIx or non-invasively estimated RM with LVMI.

Conclusion: Central AIx and RM were poorly estimated by SC and MB in children. Unlike RM(IA), none of the non-invasive indices of wave reflection correlated with LVMI, likely due to inadequate estimation of the central pressure waveform shape in this age group.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
92 - 92
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.102How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Jonathan Mynard
AU  - Greta Goldsmith
AU  - Remi Kowalski
AU  - Lucas Eastaugh
AU  - Geoff Lane
AU  - Gabriella Springall
AU  - Joe Smolich
AU  - Alberto Avolio
AU  - Michael Cheung
PY  - 2018
DA  - 2018/12/04
TI  - P49 QUANTIFYING WAVE REFLECTION IN CHILDREN: INVASIVE VS NON-INVASIVE CENTRAL AUGMENTATION INDEX AND REFLECTION MAGNITUDE AND THEIR ASSOCIATION WITH LEFT VENTRICULAR MASS
JO  - Artery Research
SP  - 92
EP  - 92
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.102
DO  - 10.1016/j.artres.2018.10.102
ID  - Mynard2018
ER  -