P48 COMPARISON BETWEEN INVASIVE AND NON-INVASIVE METHODS: TO EVALUATE AORTIC STIFFNESS BY PULSE WAVE VELOCITY

DOI

10.1016/j.artres.2018.10.101How to use a DOI?

Abstract

Objective: To investigate if invasively measured aortic pulse wave velocity (PWV) is accurately estimated by non-invasive methods purporting to assess it.

Methods: One-hundred and two patients (30% female, age 65 ± 13 years) planned to undertake coronary angiography were evaluated with the following non-invasive devices: BPLab (Petr Telegin, Russia), Complior Analyse (Alam Medical, France), Mobil-O-Graph (IEM, Germany), pOpmètre (Axelife, France), PulsePen-ET, PulsePen-ETT (Diatecne, Italy) and SphygmoCor (AtCor, Australia). Aortic PWV was measured by aortic catheterization and simultaneous measurement of pressure waves above the aortic valve and at the aortic bifurcation (FS-Stiffcath, Flag Vascular, Italy).

Results: The devices evaluating carotid-femoral PWV showed a very strong agreement between each other (r2 > 0.65) and with invasive aortic PWV (mean difference ± SD with invasive PWV: −0.73 ± 2.83 m/s (r2 = 0.41) for Complior-Analyse; 0.20 ± 2.54 m/s (r2 = 0.51) for PulsePen-ETT; −0.04 ± 2.33 m/s (r2 = 0.61) for PulsePen-ET; −0.61 ± 2.57 m/s (r2 = 0.49) for SphygmoCor). The finger-toe PWV, evaluated by the pOpmètre, and the PWV measured by BPLab showed a weak relationship with invasive PWV (respectively r 2 =0.12, 0.05), with carotid-femoral PWV measurements (r 2 =0.11, 0.010) and with age (r 2 =0.10, 0.06). PWV estimated with Mobil-O-Graph through a proprietary algorithm showed a good agreement with invasive PWV (mean difference ± SD = −1.01 ± 2.54 m/s; r2 = 0.51) and appeared to be strictly dependent on age-squared and peripheral systolic blood pressure (r2 > 0.99).

Conclusions: Methods estimating carotid-femoral PWV should be considered the only non-invasive approach to reliably assess aortic stiffness. Aortic PWV values estimated by Mobil-O-Graph algorithm are also significantly related to invasive PWV, but do not offer any additional information on top of what provided by age and systolic blood pressure levels.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Andrea Grillo
AU  - Francesco Moretti
AU  - Filippo Scalise
AU  - Andrea Faini
AU  - Matteo Rovina
AU  - Lucia Salvi
AU  - Corrado Baldi
AU  - Giovanni Sorropago
AU  - Sandrine C. Millasseau
AU  - Renzo Carretta
AU  - Alberto P. Avolio
AU  - Paolo Salvi
AU  - Gianfranco Parati
PY  - 2018
DA  - 2018/12/04
TI  - P48 COMPARISON BETWEEN INVASIVE AND NON-INVASIVE METHODS: TO EVALUATE AORTIC STIFFNESS BY PULSE WAVE VELOCITY
JO  - Artery Research
SP  - 92
EP  - 92
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.101
DO  - 10.1016/j.artres.2018.10.101
ID  - Grillo2018
ER  -