P48 COMPARISON BETWEEN INVASIVE AND NON-INVASIVE METHODS: TO EVALUATE AORTIC STIFFNESS BY PULSE WAVE VELOCITY

DOI

10.1016/j.artres.2018.10.101How to use a DOI?

Abstract

Objective: To investigate if invasively measured aortic pulse wave velocity (PWV) is accurately estimated by non-invasive methods purporting to assess it.

Methods: One-hundred and two patients (30% female, age 65 ± 13 years) planned to undertake coronary angiography were evaluated with the following non-invasive devices: BPLab (Petr Telegin, Russia), Complior Analyse (Alam Medical, France), Mobil-O-Graph (IEM, Germany), pOpmètre (Axelife, France), PulsePen-ET, PulsePen-ETT (Diatecne, Italy) and SphygmoCor (AtCor, Australia). Aortic PWV was measured by aortic catheterization and simultaneous measurement of pressure waves above the aortic valve and at the aortic bifurcation (FS-Stiffcath, Flag Vascular, Italy).

Results: The devices evaluating carotid-femoral PWV showed a very strong agreement between each other (r2 > 0.65) and with invasive aortic PWV (mean difference ± SD with invasive PWV: −0.73 ± 2.83 m/s (r2 = 0.41) for Complior-Analyse; 0.20 ± 2.54 m/s (r2 = 0.51) for PulsePen-ETT; −0.04 ± 2.33 m/s (r2 = 0.61) for PulsePen-ET; −0.61 ± 2.57 m/s (r2 = 0.49) for SphygmoCor). The finger-toe PWV, evaluated by the pOpmètre, and the PWV measured by BPLab showed a weak relationship with invasive PWV (respectively r 2 =0.12, 0.05), with carotid-femoral PWV measurements (r 2 =0.11, 0.010) and with age (r 2 =0.10, 0.06). PWV estimated with Mobil-O-Graph through a proprietary algorithm showed a good agreement with invasive PWV (mean difference ± SD = −1.01 ± 2.54 m/s; r2 = 0.51) and appeared to be strictly dependent on age-squared and peripheral systolic blood pressure (r2 > 0.99).

Conclusions: Methods estimating carotid-femoral PWV should be considered the only non-invasive approach to reliably assess aortic stiffness. Aortic PWV values estimated by Mobil-O-Graph algorithm are also significantly related to invasive PWV, but do not offer any additional information on top of what provided by age and systolic blood pressure levels.

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TY  - JOUR
AU  - Andrea Grillo
AU  - Francesco Moretti
AU  - Filippo Scalise
AU  - Andrea Faini
AU  - Matteo Rovina
AU  - Lucia Salvi
AU  - Corrado Baldi
AU  - Giovanni Sorropago
AU  - Sandrine C. Millasseau
AU  - Renzo Carretta
AU  - Alberto P. Avolio
AU  - Paolo Salvi
AU  - Gianfranco Parati
PY  - 2018
DA  - 2018/12/04
TI  - P48 COMPARISON BETWEEN INVASIVE AND NON-INVASIVE METHODS: TO EVALUATE AORTIC STIFFNESS BY PULSE WAVE VELOCITY
JO  - Artery Research
SP  - 92
EP  - 92
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.101
DO  - 10.1016/j.artres.2018.10.101
ID  - Grillo2018
ER  -