P18 AORTIC STIFFNESS IN AORTIC STENOSIS: SHORT TERM HEMODYNAMIC CHANGES AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION

DOI

10.1016/j.artres.2018.10.071How to use a DOI?

Abstract

Background: Both aortic valve stenosis as aortic stiffness are moderators of arterio-ventricular coupling and independent predictors of cardiovascular morbidity and mortality. Studies on the effect of Transcatheter Aortic Valve Implantation (TAVI) on hemodynamic parameters are limited. We performed a pilot study to investigate possible short-term hemodynamic changes after TAVI in older patients.

Methods: TAVI Care & Cure is an observational ongoing study including consecutive patients undergoing TAVI procedure. Central and peripheral hemodynamic measurements were measured non-invasively 1 day before (T0) and 1 day after (T1) TAVI using a validated oscillometric method using a brachial cuff (Mobil-O-Graph).

Results: 40 patients were included. Mean aortic valve area at baseline was 0.73 ± 0.18 cm². As expected indices of severity of the aortic valve stenosis improved. Systolic blood pressure (SBP) dropped by 8.5%, from 130.3 ± 22.9 mmHg to 119.5 ± 15.8 mmHg (p = 0.005). Diastolic blood pressure (DBP) dropped by 13.1 % from 74.8 ± 14.5 mmHg to 65.0 ± 11.3 mmHg (p < 0.001). The aPulse Wave Velocity (aPWV) decreased from 12.05 ± 1.99 m/s to 11.6 ± 1.56 m/s (p = 0.006)(Fig. 1). Patients with high aPWV at baseline showed a significantly larger reduction in SBP in comparison to patients with low aPWV: − 20.3 mmHg (−14,1%) vs – 3,1 mmHg (−2.6%), respectively (p = 0.033). The same trend was found for the DBP: −16.2 (−20.4%) v.s. −4.5 mmHg (−6.3%) for high vs. low aPWV at baseline (p=0.037).

Conclusion: We found short term changes of blood pressure and aortic stiffness after TAVI. The amplitude of the changes was the largest in patients with elevated aortic stiffness at baseline.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Jeannette Goudzwaard
AU  - Nahid El Faquir
AU  - Nicolas van Mieghem
AU  - Marjo de Ronde-Tillmans
AU  - Mattie Lenzen
AU  - Peter de Jaegere
AU  - Francesco Mattace-Raso
PY  - 2018
DA  - 2018/12/04
TI  - P18 AORTIC STIFFNESS IN AORTIC STENOSIS: SHORT TERM HEMODYNAMIC CHANGES AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION
JO  - Artery Research
SP  - 85
EP  - 85
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.071
DO  - 10.1016/j.artres.2018.10.071
ID  - Goudzwaard2018
ER  -