P21 CHARACTERIZATION OF AN ATHEROSCLEROTIC PHENOTYPE

DOI

10.1016/j.artres.2018.10.074How to use a DOI?

Abstract

Background: Interaction between gentics and epigenetics has been largely described in Atherosclerotic Disease and the relations varies widely according to the population, clinical characteristics and the study type.

Objective: Compare genetic and epigenetic factors in two middle age populations with and without plaques.

Methods: A retrospective cohort study from a database of 6381 p. first ever Non Invasive Vascular Evaluations (NIVE) (IMT, plaques, PWV and Endothelial Function (EF)). We analyzed 1876 p. 40–45 y.o. (29.4%) and particularly 179 (2, 8%) without CV Drugs, 80 w/o (P−) and 99 with C-F plaques (P+).

Results: The proportion of males (54 vs 76%), Family history + (42 vs 73%) and smokers (19 vs 30%) were higher in P+. IMT and EF were significantly abnormal but not PWV or CBP in P+.

Conclusion: In a very selective sample of middle age patients, the genetic burden and the functional alterations seem to be closely related to the presence of aterosclerosis suggesting a pathogenetic predominace over epigenetic factors.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Pedro Forcada
AU  - Castellaro Carlos
AU  - Sergio Gonzalez
AU  - Carol Kotliar
AU  - Sebastian Obregon
AU  - Jorge Chiabaut Svane
PY  - 2018
DA  - 2018/12/04
TI  - P21 CHARACTERIZATION OF AN ATHEROSCLEROTIC PHENOTYPE
JO  - Artery Research
SP  - 85
EP  - 86
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.074
DO  - 10.1016/j.artres.2018.10.074
ID  - Forcada2018
ER  -