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Volume 24, Issue C, December 2018, Pages 71 - 71

2.7 FITNESS MODIFIES THE ASSOCIATION BETWEEN EXERCISE BLOOD PRESSURE AND LEFT-VENTRICULAR MASS IN ADOLESCENCE

Authors
Zhengzheng Huang1, Ricardo Fonseca2, James Sharman2, Nish Chaturvedi3, George Smith4, Deborah Lawlor4, Laura Howe4, Chloe Park3, Alun Hughes3, Martin Schultz2, Martin Schultz2
1Menzies Institute for Medical Research, Hobart, Australia
2Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
3Institute of Cardiovascular Science, University College London, London, UK
4MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
Available Online 4 December 2018.
DOI
10.1016/j.artres.2018.10.030How to use a DOI?
Abstract

Objective: Exaggerated exercise blood pressure (BP) is associated with higher left-ventricular mass index (LVMI). Paradoxically, exercise BP and LVMI may be higher with greater fitness, but underlying factors are poorly understood. This study aimed to determine the influence of fitness on exercise BP and its relationship with LVMI in adolescents.

Methods: 4835 adolescents from the Avon Longitudinal Study of Parents and Children, aged 15.4(0.3) years, 49% male completed a submaximal cycle test. Exercise BP was measured immediately on test cessation and fitness calculated as physical work capacity 170 adjusted for lean body-mass. LVMI (n = 1589), cardiac output (CO, n = 1628) and total peripheral resistance (TPR, n = 1628) were measured by echocardiography 2.4 (0.4) years later.

Results: Each unit of fitness was associated with a 6.46 mmHg increase (95% CI: 5.83, 7.09) in exercise systolic BP. Exercise systolic BP increased step-wise by third of fitness (difference 6.06 mmHg, 95% CI:4.99, 7.13 first vs. middle; 11.13 mmHg, 10.05, 12.20 middle vs. highest). Each 5 mmHg increase in exercise systolic BP was associated with 0.25 g/m2. 7 (0.16–0.35) greater LVMI, attenuated with adjustment for fitness. There was evidence of an interaction between fitness and exercise BP on LVMI, more-marked in the middle fitness third (difference -0.27g/m2.7, -0.51,0.04 vs. first third), but similar in lowest and highest fitness thirds. CO increased (difference 0.06 L/min, -0.05,0.17; 0.23 L/min, 0.12,0.34), TPR decreased (difference -0.13AU, -0.84,0.59; -1.08AU, -0.1.80,-0.35 with fitness.

Conclusion: Fitness may modify associations between exercise BP and LVMI in adolescence. Higher CO, but lower TPR suggests a physiological exercise BP-LVMI relationship with higher fitness, rather than pathological elevations in exercise BP and LVMI.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
24 - C
Pages
71 - 71
Publication Date
2018/12/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.030How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Zhengzheng Huang
AU  - Ricardo Fonseca
AU  - James Sharman
AU  - Nish Chaturvedi
AU  - George Smith
AU  - Deborah Lawlor
AU  - Laura Howe
AU  - Chloe Park
AU  - Alun Hughes
AU  - Martin Schultz
AU  - Martin Schultz
PY  - 2018
DA  - 2018/12/04
TI  - 2.7 FITNESS MODIFIES THE ASSOCIATION BETWEEN EXERCISE BLOOD PRESSURE AND LEFT-VENTRICULAR MASS IN ADOLESCENCE
JO  - Artery Research
SP  - 71
EP  - 71
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.030
DO  - 10.1016/j.artres.2018.10.030
ID  - Huang2018
ER  -