2.8 RELATIONSHIPS BETWEEN ADIPOSITY AND LEFT VENTRICULAR FUNCTION IN ADOLESCENTS: MEDIATION BY BLOOD PRESSURE AND OTHER CARDIOVASCULAR MEASURES

Hannah Taylor; Alun D. Hughes; Abigail Fraser; Laura Howe; George Davey Smith; Debbie Lawlor; Nishi Chaturvedi; Chloe Park

doi:10.1016/j.artres.2018.10.031

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Volume 24, Issue C, December 2018, Pages 71 - 72

2.8 RELATIONSHIPS BETWEEN ADIPOSITY AND LEFT VENTRICULAR FUNCTION IN ADOLESCENTS: MEDIATION BY BLOOD PRESSURE AND OTHER CARDIOVASCULAR MEASURES

Authors

Hannah Taylor¹, Alun D. Hughes²^{, 3}, Abigail Fraser⁴, Laura Howe⁴, George Davey Smith⁴, Debbie Lawlor⁴, Nishi Chaturvedi³^{, 2}, Chloe Park²

¹University College London, London, UK

²Department of Population Science & Experimental Medicine, Institute of Cardiovascular Science, University College London, UK

³MRC Unit for Lifelong Health and Ageing at UCL, University College London, UK

⁴MRC Integrative Epidemiology Unit, University of Bristol, UK

Available Online 4 December 2018.

DOI: 10.1016/j.artres.2018.10.031 How to use a DOI?
Abstract: Introduction: Increased adiposity is associated with poorer left ventricular (LV) function but the mediating role of blood pressure (BP) and other cardiovascular measures is unknown. We investigated the roles of potential mediators in adolescents in a UK birth cohort, the Avon Longitudinal Study of Parents and Children.

Methods: Fat and lean mass were assessed by dual energy X-ray absorptiometry (DXA) in 2,068 individuals (age 17.7(SD 0.32) years; 45% male; weight 67(SD 13) kg). BP was measured and echocardiography performed. Tissue Doppler systolic (s’), early diastolic longitudinal function (e’) and transmitral E/A were used as measures of LV systolic and diastolic function respectively. Mediation was estimated using structural equation modelling; height, sex, socioeconomic position, lean mass and smoking were included as potential confounders in all models.

Results: Table 1 shows the total and direct (total – indirect (mediated)) effects (standardized β) for each potential mediator, alongside %mediation. No convincing associations were found between fat mass and s’ or e’.

Conclusions: MAP, HR and EDV, an indicator of preload, are important mediators of the effect of adiposity on diastolic function in adolescence, while TPR appears to account for none of the effect. Absence of mediation by PP, in combination with the mediation by TAC, suggests that stroke volume contributes some mediative effect. These findings emphasise the importance of adiposity and risk factor control in adolescence.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 24 - C
Pages: 71 - 72
Publication Date: 2018/12/04
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2018.10.031 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Hannah Taylor
AU  - Alun D. Hughes
AU  - Abigail Fraser
AU  - Laura Howe
AU  - George Davey Smith
AU  - Debbie Lawlor
AU  - Nishi Chaturvedi
AU  - Chloe Park
PY  - 2018
DA  - 2018/12/04
TI  - 2.8 RELATIONSHIPS BETWEEN ADIPOSITY AND LEFT VENTRICULAR FUNCTION IN ADOLESCENTS: MEDIATION BY BLOOD PRESSURE AND OTHER CARDIOVASCULAR MEASURES
JO  - Artery Research
SP  - 71
EP  - 72
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.031
DO  - 10.1016/j.artres.2018.10.031
ID  - Taylor2018
ER  -

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