P14.03 IS THERE A SHIFT OF THE REFLECTION POINT FROM PERIPHERAL TO CENTRAL ARTERIES WITH AGE IN HYPERTENSIVE PATIENTS?
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- 10.1016/j.artres.2010.10.144How to use a DOI?
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Introduction: Stiffening of arteries with age has been extensively described but this proccess has not been fully characterized at different levels of the arterial tree.
Aim: To evaluate the behavior of arterial function parameters according to age.
Methods: We screened 3277 p. derived for non-invasive vascular evaluation (NIVE) (Dec 2006/Dec 2009). NIVE comprised: IMT; PWV and FMD; atherosclerotic plaque (AP) characterization; Aortic and Peripheral pulse pressure(CPP and PPP) and Augmentation indexes (CAix and PAix). After applying exclusion criteria (age >65; diabetes mellitus, secondary HTN, previous CV events/secondary prevention) and the availability of data of PWV, CAix and PAix 1503 p. were included and analyzed according age (from 20 to 80 years old in deciles).
Results: We observed a progressive increase of all the arterial parameters with age (from 20 to 80 y.o.): PWV (8,8± 2 to 14± 4 m/sec), CPP (from 43± 15 to 59± 17mmHg), PPP (from 49± 12 to 58± 13 mmHg), CAix (from 12 to 36%) and PAix (from − 40% to 13%).
In the 50th decade a cross of values of PP (Central >Peripheral) and increase of PAix was observed suggesting a shift of the reflection point from peripheral to central arteries.
Conclusions: The stiffening of central arteries with age is associated with a progressive shift of the reflection point from peripheral to the central arteries and the loss of the pulse amplification in peripheral arteries.
Cite this article
TY - JOUR AU - P. Forcada AU - D. Olano AU - S. Gonzalez AU - S. Obregon AU - J. Chiavaut Svane AU - C. Castelaro AU - E. Cavanagh AU - F. Inserra AU - C. Kotliar PY - 2010 DA - 2010/12/02 TI - P14.03 IS THERE A SHIFT OF THE REFLECTION POINT FROM PERIPHERAL TO CENTRAL ARTERIES WITH AGE IN HYPERTENSIVE PATIENTS? JO - Artery Research SP - 186 EP - 186 VL - 4 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2010.10.144 DO - 10.1016/j.artres.2010.10.144 ID - Forcada2010 ER -