Aims: To learn endothelial function and intimal-medial thickness in patients with coronary artery disease and metabolic syndrome depending on the presence of the diabetes. 100 patients with CAD, MS, which made two clinical groups:1-st group (n-47) from CAD, MS and DT ІІ; 2-nd group (n-53) from CAD, MS without type ІІ diabetes were examined. All patients were determinated: anthropometric data, levels of glucose, lipids profile, measuring of IMT carotid artery, endothelial function of brachial artery. As a result complex intimal-medial and endothelial function in patients with CAD, MS and diabetes the IMT were higher than in the groups of patients with CAD, MS without diabetes. The positive correlation between descriptions of IMT and levels of cholesterol (r=0,68, p<0,001), LDL-cholesterol (r=0,69, p<0,001) in patients at the 1-st group was found, in this group there was negative correlation between the lipid profile and endothelial function (cholesterol r=−0,53, p<0,001, LDL-cholesterol r=−0,55, p<0,001) . In patients with CAD, MS without diabetes the faint direct correlation between the levels of cholesterol (r=−0,14, p<0,001), LDL-cholesterol (r=0,17, p<0,001) and IMT. In this group found the negative correlation between the endothelial function and levels of cholesterol (r=−0,77, p<0,001), LDL-cholesterol (r=−0,74, p<0,001. The diabetes in patients with CAD and MS associate with the increase IMT, which have close positive connection with the level of cholesterol and LDL-cholesterol. Functional changes of endothelial function have negative correlation with the lipid profile.