P11.10 ARTERIAL STRUCTURE AND FUNCTION ARE INFLUENCED BY ANTIRETROVIRAL THERAPY AND BY THE PRESENCE OF RENAL DAMAGE IN HIV POSITIVE PATIENTS

F. Cesana; A. Maloberti; M. Pozzi; M. Corciulo; G. Grosso; D. Dozio; F. Citterio; M. Alloni; S. Nava; M. Stucchi; A. Capra; C. Giannattasio; G. Mancia

doi:10.1016/j.artres.2010.10.123

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Volume 4, Issue 4, December 2010, Pages 181 - 181

P11.10 ARTERIAL STRUCTURE AND FUNCTION ARE INFLUENCED BY ANTIRETROVIRAL THERAPY AND BY THE PRESENCE OF RENAL DAMAGE IN HIV POSITIVE PATIENTS

Authors

F. Cesana¹, A. Maloberti¹, M. Pozzi¹, M. Corciulo¹, G. Grosso¹, D. Dozio¹, F. Citterio¹, M. Alloni¹, S. Nava¹, M. Stucchi¹, A. Capra¹^{, 2}, C. Giannattasio¹^{, 2}, G. Mancia¹^{, 2}

¹University of Milan Bicocca, Department of Clinical Medicine and Prevention, Monza, Italy

²Clinica Medica, San Gerardo Hospital, Monza, Italy

Available Online 2 December 2010.

DOI: 10.1016/j.artres.2010.10.123 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Purpose: Antiretroviral therapy (ART) has dramatically reduced AIDS–related mortality, but it has been associated to an increased cardiovascular risk, even in absence of hypertension. The aim of this study was to describe the influence of renal damage (RD) and ART on arterial function and structure.

Methods: We studied 4 groups of normotensive, normocholesterolemic, euglycemic patients; one of HIV+ on ART with RD (A; n=25; age 50.2±10.4 years; means±SD), one of HIV+ on ART without RD (B; n=25; 49.4±6.2 years), one of HIV+ not on ART and without RD (C; n=13; 40±8.3 years) and one of healthy controls (D; n=25; 50±6.8 years). RD was defined by microalbuminuria and/or eGFR < 60 ml/min. Arterial stiffness was measured by aorto-femoral Pulse Wave Velocity (PWV), central BP by tonometry (Sphygmocor), carotid IMT and distensibility were measured by semi-automatic echotracking.

Results: Group A showed higher aortic SBP and PP than other groups and their aortic SBP was not significantly different from systemic one. PWV was higher in both therapy groups compared to others. Aortic distensibility was significantly impaired in A compared to B and C groups (no data for D group). IMT didn’t show any difference among groups.

Conclusions: HIV+ patients are characterized by arterial functional abnormality that might account for their increased cardiovascular risk due to either ART and/or presence of RD.

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Journal: Artery Research
Volume-Issue: 4 - 4
Pages: 181 - 181
Publication Date: 2010/12/02
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2010.10.123 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - F. Cesana
AU  - A. Maloberti
AU  - M. Pozzi
AU  - M. Corciulo
AU  - G. Grosso
AU  - D. Dozio
AU  - F. Citterio
AU  - M. Alloni
AU  - S. Nava
AU  - M. Stucchi
AU  - A. Capra
AU  - C. Giannattasio
AU  - G. Mancia
PY  - 2010
DA  - 2010/12/02
TI  - P11.10 ARTERIAL STRUCTURE AND FUNCTION ARE INFLUENCED BY ANTIRETROVIRAL THERAPY AND BY THE PRESENCE OF RENAL DAMAGE IN HIV POSITIVE PATIENTS
JO  - Artery Research
SP  - 181
EP  - 181
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.123
DO  - 10.1016/j.artres.2010.10.123
ID  - Cesana2010
ER  -

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