Artery Research

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Volume 4, Issue 4, December 2010, Pages 180 - 181

P11.09 SYSTEMIC ARTERIAL PROPERTIES IN WOMEN 3 YEARS AFTER A PRE-ECLAMPTIC PREGNANCY

Authors
M.E. Estensen1, 5, E.W. Remme2, A. Swillens3, T. Henriksen4, O.A. Smiseth5, L. Gullestad5, P. Segers3, S. Aakhus5
1National Resource Centre for Women’Health, Oslo University Hospital, Rikshospitalet, Oslo, Norway
2Institute for Surgical Research, Oslo University Hospital, Rikshospitalet, Oslo, Norway
3IBiTech, Ghent University, Ghent, Belgium
4Department of Obstetrics, Oslo University Hospital, Rikshospitalet, Oslo, Norway
5Department of Cardiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.122How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Purpose: Pre-eclampsia is defined by hypertension and proteinuria, occurs in 3-10% of all pregnancies. The pathohysiological adaptation of systemic arterial properties has not been described. We performed a comprehensive study of systemic arterial properties in women with previous pre-eclamptic pregnancy (PPEP) as compared to women with previous normal pregnancy (PNP).

Methods: 35 women (37±4 years) with PPEP (3.5±1.0 years) and 65 (33±1 years) with PNP (6 months postpartum), were studied. Aortic root pressure and flow were obtained by calibrated right subclavian artery pulse trace, and aortic annular Doppler blood flow recordings. Systemic arterial properties were described by total arterial compliance(C), arterial elastance (Ea), characteristic impedance (Z0), and peripheral arterial resistance (R). Wave reflection was assessed as the ratio of the magnitude of the backward (Pb) to forward (Pf) pressure wave. Parameters were estimated by Fourier analysis of central aortic pressure and flow data and methods based on the 2-element windkessel model.

Results: (Table) Women with PPEP had significantly higher blood pressure than PNP. R was not significantly different between the groups, but Z0 and Ea were significantly higher, and C trended lower in the PPEP group. There was significantly higher amplitude in both forward and backward.

Conclusions: The higher blood pressures in women with PEP is not explained by higher peripheral arterial resistance, but is likely related to a stiffer proximal aorta, and lower arterial compliance. This may relate to the higher risk for later cardiovascular events observed in women with PEP.

PPEP PNP P
Mean arterial pressure (mmHg) 102±17 86±8 <0.001
Systolic pressure (mmHg) 129±21 110±9 0.002
Heart rate (min−1) 70±7 66±7 0.011
Cardiac output (l min−1) 5.5±1.2 4.9±0.9 0.020
R (mmHg ml−1 s−1) 1.16± 0.31 1.10±0.29 0.295
Z0 (10־3mmHg ml−1 s−1) 72±30 55±22 0.004
C WK (ml mmHg−1) 1.28±0.42 1.40±0.45 0.239
C PPM (ml mmHg−1) 1.03±0.33 1.14±0.30 0.104
Ea (mmHg ml−1) 1.45±0.39 1.27±0.28 0.004
Amplitude Forward Wave (Pf; mmHg) 36±9 30±6 0.001
Amplitude Backward Wave (Pb; mmHg) 22±8 19±4 0.017
Reflection magnitude (Pb/Pf) 0.60±0.13 0.64±0.13 0.145

Mean±SD. p<0.05 (unpaired t-test). WK = C obtained using windkessel model fit; PPM= pulse pressure method.

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Journal
Artery Research
Volume-Issue
4 - 4
Pages
180 - 181
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.122How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - M.E. Estensen
AU  - E.W. Remme
AU  - A. Swillens
AU  - T. Henriksen
AU  - O.A. Smiseth
AU  - L. Gullestad
AU  - P. Segers
AU  - S. Aakhus
PY  - 2010
DA  - 2010/12/02
TI  - P11.09 SYSTEMIC ARTERIAL PROPERTIES IN WOMEN 3 YEARS AFTER A PRE-ECLAMPTIC PREGNANCY
JO  - Artery Research
SP  - 180
EP  - 181
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.122
DO  - 10.1016/j.artres.2010.10.122
ID  - Estensen2010
ER  -