Artery Research

Volume 4, Issue 4, December 2010, Pages 178 - 178

P11.01 AMBULATORY ARTERIAL STIFFNESS INDEX (AASI) IS CORRELATED TO EA/EMAX, NOT PULSE WAVE VELOCITY IN PATIENTS WITH RESISTANT HYPERTENSION (RH) AND TYPE-II-DIABETES MELLITUS

Authors
T.K. Sønder1, B.B. Løgstrup2, J. Lambrechtsen3, L.M. Van Bortel4, P. Segers5, K. Egstrup1
1Department of Medical Research, University hospital of Odense, Svendborg hospital, Svendborg, Denmark
2Department of Cardiology, University hospital of Aarhus, Skejby hospital, Skejby, Denmark
3Department of Cardiology, University hospital of Odense, Svendborg hospital, Svendborg, Denmark
4Heymans Institute of Pharmacology, Ghent University, Ghent, Belgium
5Institute for Biomedical Technology (IBITECH), Ghent University, Ghent, Belgium
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.114How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Objective: To examine if AASI is correlated to arterial stiffness in patients with RH and type-II-diabetes mellitus.

Methods: We included 87 patients. RH was defined according to guidelines from the American Heart Association.

Echocardiography was performed using GE Vivid 7and pulse wave analysis using Sphygmocor. All examinations were performed under standardized conditions. All analyses were done blinded offline using Echopac and customized software.

Ambulatory blood pressure (BP) measurement was done using Kivex TM 2430 and Spacelab 90217. All parameters were adjusted for sex, age, length of disease and heart rate using multiple linear regression. Spearman’s rank correlation was used to estimate correlation between groups.

Results: 34 patients had RH and 24 had controlled hypertension (CH) leaving 29 with uncontrolled hypertension. See table 1 for patient characteristics. Patients were comparable with regards to age and body mass index. AASI did not differ significantly between groups. Pulse pressure, mean arterial pressure and length of disease varied significantly between groups. AASI and PWV was not correlated (Spearman’s rho = 0.08, P = 0.57).Neither was AASI and characteristic impedance (Spearman’s rho = 0.1, P=0.44) However when comparing AASI and EA/EMAX we found positive correlation (Spearman’s rho 0.36, P=0.006) and when comparing AASI and ejection fraction (Spearman’s rho = −0.29, P = 0.02) negative correlation.

Conclusion: AASI is not correlated to PWV or characteristic impedance, which are measures of arterial stiffness, but to EA/EMAX and ejection fraction, which might suggest that AASI does not reflect arterial stiffness, but ventriculo-vascular coupling.

Journal
Artery Research
Volume-Issue
4 - 4
Pages
178 - 178
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.114How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - T.K. Sønder
AU  - B.B. Løgstrup
AU  - J. Lambrechtsen
AU  - L.M. Van Bortel
AU  - P. Segers
AU  - K. Egstrup
PY  - 2010
DA  - 2010/12/02
TI  - P11.01 AMBULATORY ARTERIAL STIFFNESS INDEX (AASI) IS CORRELATED TO EA/EMAX, NOT PULSE WAVE VELOCITY IN PATIENTS WITH RESISTANT HYPERTENSION (RH) AND TYPE-II-DIABETES MELLITUS
JO  - Artery Research
SP  - 178
EP  - 178
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.114
DO  - 10.1016/j.artres.2010.10.114
ID  - Sønder2010
ER  -