P11.02 BRAIN WHITE MATTER LESIONS AND ARTERIAL WALL PARAMETERS IN MIGRAINE PATIENTS

K. Ryliskiene; D. Jatuzis; J. Usinskiene; M. Mataciunas; L. Ryliskyte; A. Laucevicius

doi:10.1016/j.artres.2010.10.115

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Volume 4, Issue 4, December 2010, Pages 178 - 179

P11.02 BRAIN WHITE MATTER LESIONS AND ARTERIAL WALL PARAMETERS IN MIGRAINE PATIENTS

Authors

K. Ryliskiene¹^{, 2}, D. Jatuzis¹^{, 2}, J. Usinskiene², M. Mataciunas²^{, 3}, L. Ryliskyte²^{, 4}, A. Laucevicius²^{, 4}

¹Vilnius University, Faculty of Medicine, Clinic of Neurology and Neurosurgery, Vilnius, Lithuania

²Vilnius University Hospital Santariskiu klinikos, Vilnius, Lithuania

³Vilnius University, Faculty of Medicine, Clinic of Thoraxal diseases, Alergology and Radiology, Vilnius, Lithuania

⁴Vilnius University, Faculty of Medicine, Clinic of Heart and Vascular Medicine, Vilnius, Lithuania

Available Online 2 December 2010.

DOI: 10.1016/j.artres.2010.10.115 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Background: Migraine is a benign neurological disease, however, some migraineurs develop asymptomatic lesions in the deep white matter (DWMLs) whose origins still need to be clarified.

Objective: To evaluate relationship between DWMLs and traditional cardiovascular risk factors, arterial wall parameters (carotid intima-media thickness, distensibility and stiffness (CS), augmentation index (AIx) and aortic pulse wave velocity) and right-to-left shunts (RLS) in migraine patients.

Methods: 114 active migraineurs (mean age 35.9±9.6 years, 22 (19.3%) males, 50 (43.9%) with aura) participated in the study. Magnetic resonance imaging was performed with a 1.5-T scanner. DWMLs load was assessed with Scheltens’ visual rating scale. Arterial wall parameters were measured by echo-tracking and applanation tonometry. RLS was assessed by contrast transcranial Doppler sonography with agitated saline. In order to explore the relationship between presence and load of DWMLs and possible risk factors logistic and linear regressions were applied.

Results: 29 (25.4%) migraineurs had DWMLs. They were significantly older (p<0.001), had more cardiovascular risk factors, thicker carotid intima-media (p=0.006), higher CS (p=0.004) and AIx (0.001) compared to migraineurs without DWMLs. The prevalence of large RLS was higher in patients with DWMLs, but not significant. The predictors of DWMLs were age (OR 1.11, p<0.001) and hypertension (OR 6.57, p=0.001). Higher DWMLs load was predicted by age, obesity, hypertension, and decreased HDL cholesterol. We established no relationship between presence and load of DWMLs and arterial wall parameters or RLS.

Conclusions: Age and traditional cardiovascular risk factors, but not arterial wall parameters, are predictors of DWMLs in patients with migraine.

<Previous Article In Issue

Download article (PDF)

Next Article In Issue>

Journal: Artery Research
Volume-Issue: 4 - 4
Pages: 178 - 179
Publication Date: 2010/12/02
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2010.10.115 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - K. Ryliskiene
AU  - D. Jatuzis
AU  - J. Usinskiene
AU  - M. Mataciunas
AU  - L. Ryliskyte
AU  - A. Laucevicius
PY  - 2010
DA  - 2010/12/02
TI  - P11.02 BRAIN WHITE MATTER LESIONS AND ARTERIAL WALL PARAMETERS IN MIGRAINE PATIENTS
JO  - Artery Research
SP  - 178
EP  - 179
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.115
DO  - 10.1016/j.artres.2010.10.115
ID  - Ryliskiene2010
ER  -

download .riscopy to clipboard