Artery Research

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Volume 4, Issue 4, December 2010, Pages 147 - 147

3.4 INSTANTANEOUS BLOOD PRESSURE IS A DETERMINANT OF AORTIC AUGMENTATION INDEX AND PULSE WAVE VELOCITY: OBSERVATIONS IN PATIENTS WITH AUTONOMIC FAILURE

Authors
A.M.T. Huijben*, F.U.S. Mattace-Raso, A.H. van den Meiracker
Erasmus University, Rotterdam, Netherlands
*Corresponding author.
Corresponding Author
A.M.T. Huijben
Available Online 2 December 2010.
DOI
10.1016/j.artres.2010.10.169How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Objective: Acute lowering of blood pressure (BP) with vasodilating agents is associated with a reduction in aortic augmentation index (AIx), whereas carotid-femoral pulse-wave velocity (cfPWV) is largely unaffected. We explored the effect of acute BP lowering on AIx and cfPWV in patients with autonomic failure (AF).

Design and method: Finger BP, Aix, cfPWV, heart rate (HR), left ventricular ejection time (LVET) and time to aortic wave reflection (TR) were obtained in supine rest and after 300 and 600 passive head-up tilting for 5min in 10 subjects with autonomic failure (age 61±15 yrs, 4 males).

Results: At baseline, MAP was 127±22 mmHg, HR 72±13bpm, LEVT 338±30 msec and TR 139±4 msec. In response to 300 and 600 tilting MAP decreased by 18.7±9.8 and 39.6±11.6%, LEVT by 11.5±3.2 and 20.4±5.5%, AIx by 39.2±27.5 and 100.9±78.1%, cfPWV by 12.0±10.5 and 27.5±13.5% and HR increased by 5.2±7.7 and 13.9±17.6% (all p<0.05), whereas TR did not change. Postural decreases in AIx were not related to changes in cfPWV. In adjusted analysis, 68% of the AIx variation during tilting could be explained by MAP and TR and 76% of the cfPWV variation by MAP and by gender.

Conclusion: Instantaneous BP is a determinant of AIx and cfPWV in AF patients. Moreover, changes in AIx are unrelated to changes in cfPWV, indicating that these measures of vascular stiffness provide different information.

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Journal
Artery Research
Volume-Issue
4 - 4
Pages
147 - 147
Publication Date
2010/12/02
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.10.169How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - A.M.T. Huijben
AU  - F.U.S. Mattace-Raso
AU  - A.H. van den Meiracker
PY  - 2010
DA  - 2010/12/02
TI  - 3.4 INSTANTANEOUS BLOOD PRESSURE IS A DETERMINANT OF AORTIC AUGMENTATION INDEX AND PULSE WAVE VELOCITY: OBSERVATIONS IN PATIENTS WITH AUTONOMIC FAILURE
JO  - Artery Research
SP  - 147
EP  - 147
VL  - 4
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.10.169
DO  - 10.1016/j.artres.2010.10.169
ID  - Huijben2010
ER  -