Artery Research

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Volume 8, Issue 4, December 2014, Pages 172 - 172

PO-16 REDUCED CARDIAC BAROREFLEX SENSITIVITY IS ASSOCIATED WITH GREATER AORTIC STIFFNESS IN MIDDLE-AGED/OLDER HUMANS: BENEFICIAL EFFECT OF HABITUAL AEROBIC EXERCISE

Authors
Stephen A. Harrisa, Harald M. Staussa, Douglas R. Sealsb, Gary L. Piercea
aDepartment of Health and Human Physiology, University of Iowa, Iowa City, IA, USA
bDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA
Available Online 4 November 2014.
DOI
10.1016/j.artres.2014.09.022How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Introduction: Sedentary aging is characterized by reduced cardiac baroreflex sensitivity (BRS) and increased aortic stiffness, both independent predictors of higher cardiovascular disease (CVD) risk in middle-aged/older (MA/O) adults. However, MA/O adults who perform habitual endurance exercise demonstrate lower CVD risk perhaps in part from reduced aortic stiffness and enhanced cardiac BRS.

Objectives: We hypothesized that reduced BRS (sequence technique derived from intra-brachial artery BP waveforms) is associated with greater aortic stiffness (aortic pulse wave velocity, aPWV) among sedentary and endurance-trained MA/O adults, and that endurance exercise training initiated in previously sedentary MA/O adults enhances BRS and reduces aPWV.

Methods and results: In a cross-sectional study, MA/O sedentary (MA/O-S, n=24, age 62 ± 4 yrs, VO2max 26 ± 1 ml/kg/min) adults demonstrated reduced BRS (11.7 ± 1.5 vs 40.7 ± 8.6 ms/mmHg, P<0.05) and greater aortic stiffness (aPWV 9.7 ± 0.8 vs. 6.4 ± 0.8 m/sec, P<0.05) compared with young sedentary (YS, n=6, age 22 ± 2 yrs; VO2max 39 ± 2 ml/kg/min) adults. MA/O endurance-trained (MA/O-T, n=15, age 61± 2 yrs, VO2max 46 ± 1 ml/kg/min, P<0.05) adults had greater BRS (24.3 ± 4.0 ms/mmHg) and smaller aPWV (8.0 ± 0.3 m/sec, P<0.05) than MA/O-S. In the entire cohort after adjustment for age and mean blood pressure, aPWV was inversely correlated with BRS (r=−0.55, P<0.05). In a subset of MA/O-S adults (n=18), 8 weeks of aerobic exercise training (n=12, 6-7 days/week, 40-45 min/day, 60-80% HRmax) improved BRS (11.7 ± 2.1 vs. 16.1 ± 2.7 ms/mmHg, P<0.05) but not aPWV (9.8 ± 0.8 vs. 9.2 ± 0.9 m/sec, P=0.08), while there was no change in sedentary time-controls (n=6, P>0.05).

Conclusions: Habitual aerobic exercise attenuates the age-related reduction in cardiac BRS and greater aortic stiffness in humans. However, short-term aerobic exercise training initiated in MA/O-S adults improves BRS but not aortic stiffness.

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Journal
Artery Research
Volume-Issue
8 - 4
Pages
172 - 172
Publication Date
2014/11/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2014.09.022How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Stephen A. Harris
AU  - Harald M. Stauss
AU  - Douglas R. Seals
AU  - Gary L. Pierce
PY  - 2014
DA  - 2014/11/04
TI  - PO-16 REDUCED CARDIAC BAROREFLEX SENSITIVITY IS ASSOCIATED WITH GREATER AORTIC STIFFNESS IN MIDDLE-AGED/OLDER HUMANS: BENEFICIAL EFFECT OF HABITUAL AEROBIC EXERCISE
JO  - Artery Research
SP  - 172
EP  - 172
VL  - 8
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.09.022
DO  - 10.1016/j.artres.2014.09.022
ID  - Harris2014
ER  -