Artery Research

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Volume 2, Issue 3, August 2008, Pages 102 - 102

P1.42 PRECLINICAL ATHEROSCLEROTIC DISEASE: IS IT A MARKER OF RISK OF CARDIOVASCULAR EVENTS?

Authors
P. Forcada1, C. Kotliar1, O. Montana2, C. Schulte2, S. Obregon1, G. Millet1, J. Guerrieri1, D. Turri1
1Hospital Universitario Austral, Pilar, Buenos Aires, Argentina
2Clinica Dim, Buenos Aires, Argentina
Available Online 15 September 2008.
DOI
10.1016/j.artres.2008.08.349How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Aim: We compared the severity of vascular disease (VD) by ultrasonography in patients (p.) with and without cardiovascular events (CVE), to detect high risk asymptomatic individuals.

Methods: We did in the same procedure 1) CIMT 2) Plaques characterization, 3) PWV and 4) FMD with a strict quality control. We set a score (VS) from 0 to 5 according to the severity of the VD. The CV Risk using Framingham score (FS) was also obtained from medical records.

Results: We performed a cross sectional, observational study on 581 p. (75 with CVE (AMI, Stroke, TIA, vascular thrombotic events) 62 + 10 y.o., 73 % males and 506 non CVE controls 52 + 14 y.o. p .001, 64% males p NS).FS was high (>20%) for 216p.(30,8%), moderate (10–20%) for 204p.(29%), and low (<10%) for 282p.(40,2%).

Parameter CVE (n= 75) No CVE (n= 506) p
SBP (mmHg) 139 ± 17 140 ± 17 NS
DBP (mmHg) 82 + 11 85 ± 10 .03
HR (bpm) 69 ± 11 70 ± 10 NS
Left IMT(mm) 0.87 ± 0.20 0.74 ± 0.19 < 001
Right IMT (mm) 0.82 ± 0.17 0.71 ± 0.18 < 001
% abnormal IMT 32 27 NS
% Plaques 77 49 < 001
%Abnormal FMD 32 36 NS
PWV (mts / sec) 12 ± 6 10 ± 4 .02
%Abnormal PWV 34 37 NS
FS (mean) 24 ± 9 13 ± 11 < 001
VS (mean) 3,2 ± 1,3 2,3 ± 1,4 < 001

Conclusions: 1-The severity of the VD is higher in patients with CVE even when the cut off points of normality may need to be adjusted.2- The presence of a combination of vascular structural and functional disarrangements in asymptomatic subjects may suggest an increased risk of CVE. 3-A score of severity of VD

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Journal
Artery Research
Volume-Issue
2 - 3
Pages
102 - 102
Publication Date
2008/09/15
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2008.08.349How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - P. Forcada
AU  - C. Kotliar
AU  - O. Montana
AU  - C. Schulte
AU  - S. Obregon
AU  - G. Millet
AU  - J. Guerrieri
AU  - D. Turri
PY  - 2008
DA  - 2008/09/15
TI  - P1.42 PRECLINICAL ATHEROSCLEROTIC DISEASE: IS IT A MARKER OF RISK OF CARDIOVASCULAR EVENTS?
JO  - Artery Research
SP  - 102
EP  - 102
VL  - 2
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2008.08.349
DO  - 10.1016/j.artres.2008.08.349
ID  - Forcada2008
ER  -