Artery Research

Volume 2, Issue 3, August 2008, Pages 95 - 95

P1.13 ENHANCED VASCULAR REACTIVITY TO COLD PRESSOR TEST IN AFRICAN NORMOTENSIVE SUBJECTS

Authors
D. Adamopoulos, W. Ngatsou, D. Lemogoum, B. Biholong, S. Beloka, O. Lheureux, P. Kayembe, J.P. Degaute, P. van de Borne
Erasme Hospital, Dept. of Cardiology, ULB, Brussels, Belgium
Available Online 15 September 2008.
DOI
10.1016/j.artres.2008.08.321How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Cold exposure increases arterial wave reflection to the aorta mainly through adrenergic vasoconstriction. Normotensive blacks exhibit heightened sympathetic response to cold as compared to Whites controls. We therefore decided to test the hypothesis that cold exposure would elicit a greater increase in arterial wave reflection in normotensive Africans when compared to normotensive Caucasian subjects. In addition we sought to investigate whether this would be accompanied by a higher increase in aortic pulse wave velocity (PWV) and by a more pronounced vasoconstriction of the skin microcirculation.

Methods: 17 young normotensive Africans and 17 age and weight matched Caucasians were recruited for the study. All underwent assessment of PWV and Augmentation Index corrected for heart rate (AIx) at rest, during and after hand immersion in ice water (cold pressor test, [CPT]). Concomitantly, skin microvascular blood flow response to cold was continuously monitored by laser Doppler flowmetry method.

Results: At rest, Africans exhibited higher values of PWV than Caucasians (7.3±0.3 vs 6.4±0.2 m/sec respectively, p=0.04). During CPT the magnitudes of increases in SBP and PWV were greater in Africans than Caucasians (26±3 mmHg vs 15±3 mmHg and 0.8±0.2 m/sec vs 0.4±0.2 m/sec respectively, p<0.05 for all). Additionally, CPT induced a more pronounced skin microvascular vasoconstriction in Africans as compared to Caucasians (−45±7 % vs −25±7 %, p=0.01). Finally, Africans exhibited higher AIx values during CPT (12.6±2.4 vs 5.5±2.4 %, p=0.04) when compared to Caucasian subjects.

Conclusions: Normotensive Africans exhibit intensified wave reflection to the aorta as response to CPT when compared to Caucasians. This is accompanied by a greater increase in PWV and a more pronounced vasoconstriction of the microcirculation.

Journal
Artery Research
Volume-Issue
2 - 3
Pages
95 - 95
Publication Date
2008/09/15
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2008.08.321How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - D. Adamopoulos
AU  - W. Ngatsou
AU  - D. Lemogoum
AU  - B. Biholong
AU  - S. Beloka
AU  - O. Lheureux
AU  - P. Kayembe
AU  - J.P. Degaute
AU  - P. van de Borne
PY  - 2008
DA  - 2008/09/15
TI  - P1.13 ENHANCED VASCULAR REACTIVITY TO COLD PRESSOR TEST IN AFRICAN NORMOTENSIVE SUBJECTS
JO  - Artery Research
SP  - 95
EP  - 95
VL  - 2
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2008.08.321
DO  - 10.1016/j.artres.2008.08.321
ID  - Adamopoulos2008
ER  -