Artery Research

Volume 2, Issue 3, August 2008, Pages 87 - 87

03.02 EVIDENCE OF A “COMMON” RESERVOIR PRESSURE TRANSMITTED ALONG THE LENGTH OF THE AORTA WHICH IS THE PREDOMINATE DETERMINATE OF ARTERIAL PRESSURE IN HUMANS

Authors
S.M.E. Ieng1, J.E. Davies1, J. Baksi1, D.P. Francis1, K.H. Parker2, J.M. Mayet1, A.D. Hughes1
1Imperial College NHS Trust, International Centre for Circulatory Health, St Mary’s Campus, Imperial College, London, United Kingdom
2Physiological Flow Unit, Imperial College, London, United Kingdom
Available Online 15 September 2008.
DOI
10.1016/j.artres.2008.08.290How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Despite the large variation in pulse pressure waveform throughout the aorta, the diastolic decay of the pressure waveform is almost identical. We hypothesise that this is because there is a common reservoir pressure along the entire aorta, principally determined by the highly elastic proximal aortic root. We apply a new technique to calculate this reservoir pressure along the aorta to test this hypothesis.

Method and Results: Using intra-arterial wires, pressure and Doppler velocity were measured at 10cm intervals along the aorta in 16 patients (aged 55±11 years). Pressure was separated into reservoir and wave components using the new wave-reservoir technique. In all patients, the intra-subject reservoir pressure waveforms were almost identical (mean correlation coefficient 0.99±0.01) regardless of the marked changes in the measured pressure waveform (systolic pressure p=0.020 and pulse pressure p=0.001). Significant variation in reservoir pressure was seen between subjects (peak reservoir = 63.4 – 21.4 mmHg). The reservoir pressure was the predominate determinant of the pressure waveform and accounted for 67.0 ± 8.8% of the total integrated pulse pressure across all aortic sites.

Conclusions: The aortic pressure waveform is predominately determined by the reservoir pressure. This reservoir pressure is similar along the length of the aorta despite marked changes in the shape of the measured pressure waveform. Manipulation of the arterial reservoir, rather than wave-reflection sites may be more important in regulation of blood pressure control.

Journal
Artery Research
Volume-Issue
2 - 3
Pages
87 - 87
Publication Date
2008/09/15
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2008.08.290How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - S.M.E. Ieng
AU  - J.E. Davies
AU  - J. Baksi
AU  - D.P. Francis
AU  - K.H. Parker
AU  - J.M. Mayet
AU  - A.D. Hughes
PY  - 2008
DA  - 2008/09/15
TI  - 03.02 EVIDENCE OF A “COMMON” RESERVOIR PRESSURE TRANSMITTED ALONG THE LENGTH OF THE AORTA WHICH IS THE PREDOMINATE DETERMINATE OF ARTERIAL PRESSURE IN HUMANS
JO  - Artery Research
SP  - 87
EP  - 87
VL  - 2
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2008.08.290
DO  - 10.1016/j.artres.2008.08.290
ID  - Ieng2008
ER  -