P3.05 EFFECTS OF ACETAZOLAMIDE ON BLOOD PRESSURE AND PULSE WAVEFORM CHANGES INDUCED BY HIGH ALTITUDE EXPOSURE
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Background: Exposure to high altitude (HA) may induce mountain sickness and increase blood pressure (BP) but little is known on the effects on arterial properties. Acetazolamide (AC) has been proposed to prevent and treat mountain sickness, but no information is available on its effects on cardiovascular parameters at HA. Our aim was to assess these issues in healthy volunteers acutely exposed to very HA.
Methods: 42 subjects (age 36.8±8.9, 21 Male) were randomized to double blind AC 250 mg bid or placebo (PL). Arterial tonometry (PulsePen, DiaTecne, Milan) including carotid-femoral and carotid-radial PWV (CF-PWV,CR-PWV) and pulse wave analysis (augmentation index, AIx and subendocardial viability ratio, SEVR) was performed: at baseline (BAS), after 2 days of treatment at sea level (SLpost); within 6 hours from arrival at Capanna Margherita(Mount Rosa, 4559 m,HA1); and on 3rd full day of exposure to HA(HA2). Systolic (S) and diastolic (D)BP were measured with validated oscillometric device (AND UA 767-PC). Heart rate (HR) was derived from the ECG signal. Data are shown as means±SD.
Results. (See table, p=peripheral, c= central, M=mean). At HA, AIx (adjusted for HR) increased but was significantly lower in AC group, moreover AC treatment partially counteracted the decrease in SEVR.
Conclusions: Acute exposure to HA induced both a BP rise and changes in vascular function, partly counteracted by treatment with AC. These haemodynamic effects may contribute to the beneficial role of AC at HA and may have implications for the possible clinical usefulness of AC in patients with hypoxemia.
| BAS | SLpost | HAl | HA2 | |||||
|---|---|---|---|---|---|---|---|---|
| PL | AC | PL | AC | PL | AC | PL | AC | |
| pSBP | 114.8±12.2 | 115.4±13.4 | 114.5±12.2 | 110.1±12.8 | 115.7±9.8 | 108.3±9.6# | 120.7±8.*° | 114.2±11.7 |
| cSBP | 109.5±11.1 | 110.1±14.4 | 109.3±11.7 | 107.5±12.8 | 110.3±9 | 104.6±9.6 | 115.4±7.8* | 109.6±12.3 |
| MBP | 89.2±8.3 | 88.0±9.1 | 87.8±8.3 | 84.9±8.5 | 92.7±6.8° | 85.3±6.0 # | 96.8±6.8*· | 91.2±8.3 # |
| DBP | 72.1±6.7 | 69.8±7.3 | 70.1±6.9 | 68.1±63 | 77.4±6.8 * | 70.1±5.3 # | 89.9±7.5 *° | 74.1±7.3 °§ |
| HR | 59.5±6.4 | 64.1±9.4 | 57.6±5.5 | 58.2±6.6* | 83.5±10.4 *· | 76.4±8.8 *°# | 68.7±10.9 *°§ | 63.3±9.8 °§ |
| Alx75 | −8.4±12.5 | −11.7±10.9 | −7.3±11.3 | −15.5±10# | 1.54±12.6 *° | −7.5±12.6 °# | 2.1±11.8 *° | −8.1±10.9 °# |
| SEVR | 0.88±0.14 | 0.78±0.23 | 0.89±0.19 | 0.87±0.2 | 0.58±0.14 *° | 0.67±0.13 ° | 0.74±0.17 *°§ | 0.87±0.15 §# |
| cf-PWV | 6.3±1.1 | 6.4±1.3 | 6.7±2.3 | 6.0±1.1 | 6.6±1.2 | 5.9±0.9 | 6.3±1.1 | 6.0±0.8 |
| cr-PWV | 7.7±11 | 7.7±1.2 | 8.1±1.7 | 7.9±1.3 | 6.7±1.5 | 8.3±1.6 | ||
p<0.05 Vs Slpre;
p<0.05 Vs Slpost;
p<0.05 Vs HA1;
p<0.05 Vs PL at same step
Cite this article
TY - JOUR AU - M. Revera AU - P. Salvi AU - A. Giuliano AU - G. Bilo AU - A. Faini AU - F. Gregorini AU - C. Lombardi AU - G. Mancia AU - G. Parati PY - 2011 DA - 2011/11/29 TI - P3.05 EFFECTS OF ACETAZOLAMIDE ON BLOOD PRESSURE AND PULSE WAVEFORM CHANGES INDUCED BY HIGH ALTITUDE EXPOSURE JO - Artery Research SP - 157 EP - 157 VL - 5 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2011.10.040 DO - 10.1016/j.artres.2011.10.040 ID - Revera2011 ER -