P3.06 RELATION BETWEEN HAPTOGLOBIN PHENOTYPE AND ARTERIAL STIFFNESS IN NEWLY DIAGNOSED UNTREATED HYPERTENSIVE PATIENTS

C. Strandhave; M. Svensson; K. Holdensen; C.M. Skov; H. Krarup; J.H. Christensen

doi:10.1016/j.artres.2011.10.041

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Volume 5, Issue 4, December 2011, Pages 158 - 158

P3.06 RELATION BETWEEN HAPTOGLOBIN PHENOTYPE AND ARTERIAL STIFFNESS IN NEWLY DIAGNOSED UNTREATED HYPERTENSIVE PATIENTS

Authors

C. Strandhave¹, M. Svensson², K. Holdensen¹, C.M. Skov¹, H. Krarup³, J.H. Christensen¹

¹Dept. of Nephrology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark

²Dept. of Nephrology, Skejby Hospital, Aarhus University Hospital, Aarhus, Denmark

³Dept. of Clinical Biochemistry, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark

Available Online 29 November 2011.

DOI: 10.1016/j.artres.2011.10.041 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Arterial stiffness is a valuable predictor of cardiovascular risk in essential hypertension. Arterial stiffness is affected by several factors including genetic polymorphisms. Moreover, increased arterial stiffness has been associated with oxidative stress. Haptoglobin (Hp) is an innate antioxidant which due to molecular heterogeneity forms three phenotypes: 1-1, 2-1, and 2-2. The antioxidant ability is phenotype dependent. In diabetes mellitus Hp 2-2 is a predictor of vascular complications but whether Hp 2-2 predicts vascular complications in essential arterial hypertension has not previously been examined.

The aim of the study was to investigate if Hp 2-2 was positively associated with aortic pulse wave velocity (aPWV) and central systolic blood pressure (sysBP).

We examined 94 newly diagnosed untreated hypertensive patients. aPWV and central sysBP were measured using the SphygmoCor device. Hp phenotype was determined using high-performance liquid chromatography.

The cohort consisted of 42 men and 52 women with an average age of 48 ± 11 years. The median aPWV was 7.6 (6.0; 9.7) m/s in Hp 1-1, 8.0 (5.3; 11.0) m/s in Hp 2-1, and 8.3 (5.5; 10.6) m/s in Hp 2-2. The difference was non-significant (p=0.5, ANOVA). The median central sysBP was 147 (123; 163) mmHg in Hp 1-1, 151 (123; 187) mmHg in Hp 2-1, and 155 (124; 195) mmHg in Hp 2-2. Also, these differences were non-significant (p=0.4, ANOVA).

This study showed a potential yet non-significant difference in aPWV and in central sysBP between Hp phenotypes with the highest levels in Hp 2-2 hypertensive patients.

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Journal: Artery Research
Volume-Issue: 5 - 4
Pages: 158 - 158
Publication Date: 2011/11/29
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2011.10.041 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - C. Strandhave
AU  - M. Svensson
AU  - K. Holdensen
AU  - C.M. Skov
AU  - H. Krarup
AU  - J.H. Christensen
PY  - 2011
DA  - 2011/11/29
TI  - P3.06 RELATION BETWEEN HAPTOGLOBIN PHENOTYPE AND ARTERIAL STIFFNESS IN NEWLY DIAGNOSED UNTREATED HYPERTENSIVE PATIENTS
JO  - Artery Research
SP  - 158
EP  - 158
VL  - 5
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.10.041
DO  - 10.1016/j.artres.2011.10.041
ID  - Strandhave2011
ER  -

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