P2.12 THE INTERPLAY OF ENDOTHELIAL FUNCTION, INFLAMMATORY AND OXIDATIVE STATUS IN HIV INFECTION. DOES ANTIRETROVIRAL THERAPY PLAY A ROLE?

P. Xaplanteris; C. Vlachopoulos; E. Mariolis; E. Sambatakou; D. Terentes-Printzios; N. Ioakeimidis; D. Kardara; A. Synodinos; C. Stefanadis

doi:10.1016/j.artres.2011.10.033

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Volume 5, Issue 4, December 2011, Pages 155 - 156

P2.12 THE INTERPLAY OF ENDOTHELIAL FUNCTION, INFLAMMATORY AND OXIDATIVE STATUS IN HIV INFECTION. DOES ANTIRETROVIRAL THERAPY PLAY A ROLE?

Authors

P. Xaplanteris¹, C. Vlachopoulos¹, E. Mariolis², E. Sambatakou², D. Terentes-Printzios¹, N. Ioakeimidis¹, D. Kardara¹, A. Synodinos¹, C. Stefanadis¹

¹1st Dept of Cardiology, Hippokration Hospital, Athens Medical School, Athens, Greece

²2nd Dept of Internal Medicine and Infectious Diseases, Hippokration Hospital, Athens Medical School, Athens, Greece

Available Online 29 November 2011.

DOI: 10.1016/j.artres.2011.10.033 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Purpose: HIV infection is linked to heightened cardiovascular risk; this is partly mediated through endothelial dysfunction. We investigated the interplay of endothelial function with markers of inflammatory and oxidation in two groups of HIV infected patients: on ART and naïve to ART.

Methods: We recruited 47 HIV infected patients (46 male, mean age 35±10 years, mean CD4 count: 579±271). All were free from overt cardiovascular disease. 31 patients were naïve to ART; 17 were on ART. FMD of the brachial artery was used as an index of endothelial function. Markers of inflammatory (CRP, IL6), oxidative (ADMA) and functional (CD4, viral load) status were measured. Between groups comparisons (ART vs naïve patients) were performed using the Mann-Whitney U test.

Results: Endothelial function and inflammatory markers did not differ across groups. ART group had higher ADMA levels, lower viral load and higher CD4 count, thereby a favorable oxidative/functional status compared to naïves.

	Naïve (n=31)	ART (n=17)	P value
FMD (%)	4.2 (2.3, 7.5)	5.2 (3.1, 8.2)	0.740
CRP (mg/dL)	1.37 (0.98, 2.79)	1.05 (0.28, 3.32)	0.249
IL6 (pg/mL)	1.65 (0.83, 3.39)	1.00 (0.77, 1.65)	0.258
ADMA (μmol/L)	0.63 (0.25, 0.79)	0.84 (0.78, 1.06)	0.006
Viral load	19419 (8144, 54025)	50 (50, 50)	0.001
CD4 count	450 (378, 627)	635 (510, 779)	0.011

Conclusion: In HIV infection, ART does not change endothelial function; nevertheless it is linked to a favorable oxidative and functional status.

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Journal: Artery Research
Volume-Issue: 5 - 4
Pages: 155 - 156
Publication Date: 2011/11/29
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2011.10.033 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - P. Xaplanteris
AU  - C. Vlachopoulos
AU  - E. Mariolis
AU  - E. Sambatakou
AU  - D. Terentes-Printzios
AU  - N. Ioakeimidis
AU  - D. Kardara
AU  - A. Synodinos
AU  - C. Stefanadis
PY  - 2011
DA  - 2011/11/29
TI  - P2.12 THE INTERPLAY OF ENDOTHELIAL FUNCTION, INFLAMMATORY AND OXIDATIVE STATUS IN HIV INFECTION. DOES ANTIRETROVIRAL THERAPY PLAY A ROLE?
JO  - Artery Research
SP  - 155
EP  - 156
VL  - 5
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.10.033
DO  - 10.1016/j.artres.2011.10.033
ID  - Xaplanteris2011
ER  -

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