Correlation between fetuin-A and matrix Gla protein levels in human serum
- DOI
- 10.1016/j.artres.2010.06.002How to use a DOI?
- Keywords
- Fetuin-A; Matrix Gla protein; Osteoprotegerin; Osteopontin; Vascular calcification
- Abstract
Background: Vascular calcification is frequently found in hemodialysis patients. Fetuin-A is a well-characterized circulating inhibitor of calcification. Several other bone-associated proteins, such as the matrix Gla protein (MGP), osteoprotegerin (OPG), and osteopontin (OPN), are also presumed to inhibit vascular calcification. However, little is known about the relationship between fetuin-A and other calcification inhibitors. In this study, we examined the association of fetuin-A with MGP, OPG, and OPN.
Methods: We consecutively enrolled 92 subjects who were suspected to have coronary artery diseases. Serum levels of fetuin-A, MGP, OPG, and OPN were measured using ELISA.
Results: Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels.
Conclusions: We found the positive correlation between fetuin-A and MGP levels in human serum. Fetuin-A may collaborate with MGP to inhibit vascular calcification.
- Copyright
- © 2010 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
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TY - JOUR AU - Katsuhito Mori AU - Yuji Ikari AU - Shuichi Jono AU - Masanori Emoto AU - Atsushi Shioi AU - Hidenori Koyama AU - Tetsuo Shoji AU - Eiji Ishimura AU - Masaaki Inaba AU - Kazuhiro Hara AU - Yoshiki Nishizawa PY - 2010 DA - 2010/07/24 TI - Correlation between fetuin-A and matrix Gla protein levels in human serum JO - Artery Research SP - 91 EP - 93 VL - 4 IS - 3 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2010.06.002 DO - 10.1016/j.artres.2010.06.002 ID - Mori2010 ER -