Artery Research

Volume 4, Issue 3, September 2010, Pages 91 - 93

Correlation between fetuin-A and matrix Gla protein levels in human serum

Authors
Katsuhito Moria, *, Yuji Ikaric, Shuichi Jonoa, Masanori Emotoa, Atsushi Shioib, Hidenori Koyamaa, Tetsuo Shojia, Eiji Ishimuraa, Masaaki Inabaa, Kazuhiro Harac, Yoshiki Nishizawaa
aThe Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, Japan
bThe Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan
cThe Division of Cardiology, Mitsui Memorial Hospital, Tokyo, Japan
*Corresponding author. Tel.: +81 6 6645 3806; fax: +81 6 6645 3808. E-mail address: ktmori@med.osaka-cu.ac.jp (K. Mori).
Corresponding Author
Katsuhito Mori
Received 16 March 2010, Revised 27 May 2010, Accepted 7 June 2010, Available Online 24 July 2010.
DOI
10.1016/j.artres.2010.06.002How to use a DOI?
Keywords
Fetuin-A; Matrix Gla protein; Osteoprotegerin; Osteopontin; Vascular calcification
Abstract

Background: Vascular calcification is frequently found in hemodialysis patients. Fetuin-A is a well-characterized circulating inhibitor of calcification. Several other bone-associated proteins, such as the matrix Gla protein (MGP), osteoprotegerin (OPG), and osteopontin (OPN), are also presumed to inhibit vascular calcification. However, little is known about the relationship between fetuin-A and other calcification inhibitors. In this study, we examined the association of fetuin-A with MGP, OPG, and OPN.

Methods: We consecutively enrolled 92 subjects who were suspected to have coronary artery diseases. Serum levels of fetuin-A, MGP, OPG, and OPN were measured using ELISA.

Results: Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels.

Conclusions: We found the positive correlation between fetuin-A and MGP levels in human serum. Fetuin-A may collaborate with MGP to inhibit vascular calcification.

Copyright
© 2010 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
4 - 3
Pages
91 - 93
Publication Date
2010/07/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.06.002How to use a DOI?
Copyright
© 2010 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Katsuhito Mori
AU  - Yuji Ikari
AU  - Shuichi Jono
AU  - Masanori Emoto
AU  - Atsushi Shioi
AU  - Hidenori Koyama
AU  - Tetsuo Shoji
AU  - Eiji Ishimura
AU  - Masaaki Inaba
AU  - Kazuhiro Hara
AU  - Yoshiki Nishizawa
PY  - 2010
DA  - 2010/07/24
TI  - Correlation between fetuin-A and matrix Gla protein levels in human serum
JO  - Artery Research
SP  - 91
EP  - 93
VL  - 4
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.06.002
DO  - 10.1016/j.artres.2010.06.002
ID  - Mori2010
ER  -