Artery Research

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Volume 4, Issue 2, June 2010, Pages 47 - 51

The effects of weight loss using dietary manipulation and rimonabant therapy on arterial stiffness in type 2 diabetes

Authors
A. Chakera, S. Bunce, C. Heppenstall, J.C. Smith*
Department of Diabetes & Endocrinology, Torbay Hospital, Lawes Bridge, Torquay, Devon TQ2 7AA, UK
*Corresponding author. Tel.: +44 (0) 1803 654923; fax: +44 (0) 1803 655741. E-mail address: jamie.smith2@nhs.net (J.C. Smith).
Corresponding Author
J.C. Smith
Received 4 January 2010, Revised 26 March 2010, Accepted 8 April 2010, Available Online 30 April 2010.
DOI
10.1016/j.artres.2010.04.001How to use a DOI?
Keywords
Diabetes; Arterial stiffness; Obesity
Abstract

Background: Obesity is considered an important factor contributing to premature arterial stiffening in type 2 diabetes but it is uncertain whether weight loss through dietary modification leads to a reduction in arterial stiffness. Rimonabant is an anti-obesity drug which, through its pharmacological action of cannabinoid receptor blockade, could exert effects on central haemodynamics.

Methods: In an open design, 29 obese subjects with type 2 diabetes were studied. Subjects were studied before, during and after 6 months dietary intervention with (20 subjects), or without (9 subjects) rimonabant. Arterial stiffness (aortic and brachial pulse wave velocity), central aortic pressure and wave reflection were assessed non-invasively (Sphygmocor).

Results: After 6 months (in comparison with baseline), there were reductions in weight (104 ± 21 versus 107 ± 21 Kg, p < 0.001), and improvements in HbA1c (7.3 ± 1.4 at 3 months, p < 0.01 and 7.4 ± 1.5 at 6 months, p = 0.06 versus 7.7 ± 1.5% at baseline) and HDL cholesterol (1.3 ± 0.2 versus 1.2 ± 0.3 mmol/L, p < 0.001). Aortic diastolic pressure (82 ± 10 versus 85 ± 8 mmHg, p < 0.05) was lowered despite unchanged peripheral mean arterial pressure. No reductions in aortic stiffness or wave reflection were observed.

Conclusion: Dietary manipulation led to significant weight loss and favourable metabolic effects. These beneficial changes did not lead to a reduction in aortic stiffness or pressure wave reflection despite a fall in central aortic blood pressure.

Copyright
© 2010 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
4 - 2
Pages
47 - 51
Publication Date
2010/04/30
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2010.04.001How to use a DOI?
Copyright
© 2010 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - A. Chakera
AU  - S. Bunce
AU  - C. Heppenstall
AU  - J.C. Smith
PY  - 2010
DA  - 2010/04/30
TI  - The effects of weight loss using dietary manipulation and rimonabant therapy on arterial stiffness in type 2 diabetes
JO  - Artery Research
SP  - 47
EP  - 51
VL  - 4
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2010.04.001
DO  - 10.1016/j.artres.2010.04.001
ID  - Chakera2010
ER  -