Artery Research

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Volume 3, Issue 4, December 2009, Pages 159 - 159

8.1 CENTRAL ARTERIAL STIFFNESS OCCURS IN BRONCHIECTASIS

Authors
N.S. Gale1, J.M. Duckers2, M. Munnery3, S. Enright1, J.R. Cockcroft3, C.E. Bolton2, D.J. Shale2
1School of Healthcare Studies, Cardiff University, Cardiff, United Kingdom
2Department of Respiratory Medicine, Cardiff University, Cardiff, United Kingdom
3Wales Heart Research Institute, Cardiff University, Cardiff, United Kingdom
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.173How to use a DOI?
Abstract

Rationale: Bronchiectasis is characterised by inflammation and airways injury, which lead to loss of airways function, factors which are associated with an increased risk of cardiovascular disease (CVD) in various populations. Central arterial stiffness (AS) a predictor of CVD risk has not been studied in bronchiectasis. We hypothesised that patients with bronchiectasis would have increased AS.

Methods: We studied 20 clinically stable patients with bronchiectasis and 20 age, sex and smoking matched controls, without evidence of CVD. In all subjects we determined FEV1, aortic pulse wave velocity (PWV), fasting lipids and systemic inflammation (IL-6).

Results: Aortic PWV and IL-6 were greater in patients, than controls (p<0.05), while age, BMI, lipids and MAP were similar for patients and controls. In all subjects age was the only predictor of aortic PWV (p<0.01).

Conclusions: Patients with bronchiectasis have increased AS, as determined by aortic PWV, which indicates an increased risk of CVD. Longer term studies are needed to determine the importance of this finding.

Mean (SD) Control (n=20) Patient (n=20)
Men n (%) 4 (20) 4 (20)
Age (yrs) § 62 (43–69) 65 (42–80)
Smoking Pack yrs § 0 (0–30) 0 (0–30)
FEV1 (% predicted) 105.1 (9.1) 67.8 (25.8)**
Heart rate (bpm) 65.4 (9.4) 73.0 (11.9)*
MAP (mmHg) 100.1 (14.3) 103.2 (12.0)
Aortic PWV (m/s) 8.8 (1.6) 10.5 (3)*
AIx (%) 29.6 (8.8) 28.8 (8.7)
IL-6 (pg/ml) † 1.19 (3.7) 4.41 (5.81)*
*

p<0.05;

**

p<0.001 difference.

§

median (range).

†

geometric mean (SD).

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
3 - 4
Pages
159 - 159
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.173How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - N.S. Gale
AU  - J.M. Duckers
AU  - M. Munnery
AU  - S. Enright
AU  - J.R. Cockcroft
AU  - C.E. Bolton
AU  - D.J. Shale
PY  - 2009
DA  - 2009/12/03
TI  - 8.1 CENTRAL ARTERIAL STIFFNESS OCCURS IN BRONCHIECTASIS
JO  - Artery Research
SP  - 159
EP  - 159
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.173
DO  - 10.1016/j.artres.2009.10.173
ID  - Gale2009
ER  -