Artery Research

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Volume 3, Issue 4, December 2009, Pages 158 - 158

6.6 WAIST CIRCUMFERENCE IS A BETTER PREDICTOR OF SUBCLINICAL ATHEROSCLEROSIS THAN ADIPONECTIN LEVEL

Authors
S. Holewijn1, M. den Heijer2, L.J. van Tits1, D.W. Swinkels3, A.F.H. Stalenhoef1, J. de Graaf1
1Radboud University Nijmegen Medical Centre, Department of General Internal Medicine, Nijmegen, Netherlands
2Radboud University Nijmegen Medical Centre, Department of Epidemiology and Biostatistics, Nijmegen, Netherlands
3Radboud University Nijmegen Medical Centre, Department of Clinical Chemistry, Nijmegen, Netherlands
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.171How to use a DOI?
Abstract

Objective: Waist circumference is clinical marker of obesity and a well-established risk factor for cardiovascular disease. Adiponectin, an adipocyte-derived hormone and new biomarker of obesity, has recently been proposed to be the missing link between obesity and increased cardiovascular risk. We evaluated waist circumference and adiponectin level in a middle-aged population-based cohort to determine which marker of obesity was the best predictor of subclinical atherosclerosis.

Methods and Results: Seven non-invasive measurements of atherosclerosis(NIMA), as surrogate markers of subclinical atherosclerosis, were determined in 1517 participants of the Nijmegen Biomedical Study, aged 50–70 years who were drawn from the Dutch community.

Both men and women with a high waist(M>104cm;F>95cm) showed deteriorated outcomes of NIMA as reflected by increased pulse wave velocity(PWV)(M:+12.6%;F:+13.1%) and thicker intima-media thickness (IMT)(M:+9.0%;F:+6.6%) and in women an increased plaque thickness(+22.1%). However, participants with a low adiponectin level(M<2.2mg/L;F< 3.5mg/L) showed no changes in the outcomes of NIMA; in both sexes only after adjustment for age a decreased ankle-brachial index after exercise(M: −9%;F: −3.5%) and an increased IMT(M:3.7%;F:3.6%) and in women an increased PWV(+6.8%) was observed. Interaction between the effect of waist and adiponectin on NIMA was found only in women.

Conclusions: Waist circumference was a better predictor of subclinical atherosclerosis than adiponectin level in our large population-based cohort. Measurement of waist circumference in clinical practice is a valuable tool in cardiovascular risk profiling, but our data does not support the measurement of adiponectin level.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
3 - 4
Pages
158 - 158
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.171How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - S. Holewijn
AU  - M. den Heijer
AU  - L.J. van Tits
AU  - D.W. Swinkels
AU  - A.F.H. Stalenhoef
AU  - J. de Graaf
PY  - 2009
DA  - 2009/12/03
TI  - 6.6 WAIST CIRCUMFERENCE IS A BETTER PREDICTOR OF SUBCLINICAL ATHEROSCLEROSIS THAN ADIPONECTIN LEVEL
JO  - Artery Research
SP  - 158
EP  - 158
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.171
DO  - 10.1016/j.artres.2009.10.171
ID  - Holewijn2009
ER  -