3.6 OSTEOPROTEGERIN IS ASSOCIATED INDEPENDENTLY WITH AORTIC STIFFNESS IN PATIENTS WITH ATHEROSCLEROSIS AND IN HEALTHY SUBJECTS

M. Zagura; M. Sergejev; J. Lieberg; P. Kampus; A. Peetsalu; J. Eha; M. Zilmer; J. Kals

doi:10.1016/j.artres.2009.10.157

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Volume 3, Issue 4, December 2009, Pages 154 - 154

3.6 OSTEOPROTEGERIN IS ASSOCIATED INDEPENDENTLY WITH AORTIC STIFFNESS IN PATIENTS WITH ATHEROSCLEROSIS AND IN HEALTHY SUBJECTS

Authors

M. Zagura¹, M. Sergejev², J. Lieberg³, P. Kampus⁴, A. Peetsalu⁵, J. Eha⁶, M. Zilmer⁷, J. Kals⁸

¹Department of Biochemistry, University of Tartu, Tartu, Estonia

²Department of Cardiology, University of Tartu, Tartu, Estonia

³Department of Surgery, University of Tartu, Tartu, Estonia

⁴Department of Cardiology, University of Tartu, Tartu, Estonia

⁵Department of Surgery, University of Tartu, Tartu, Estonia

⁶Department of Cardiology, University of Tartu, Tartu, Estonia

⁷Department of Biochemistry, University of Tartu, Tartu, Estonia

⁸Department of Biochemistry, University of Tartu, Tartu, Estonia

Available Online 3 December 2009.

DOI: 10.1016/j.artres.2009.10.157 How to use a DOI?
Abstract: Background: Arterial stiffening is an independent predictor for cardiovascular mortality. Preliminary studies have shown that arterial calcification may have impact on increased vascular stiffness. However, little is known about the role of calcification inhibitor osteoprotegerin (OPG) as an independent predictor of arterial stiffness in patients with peripheral arterial disease (PAD) and in healthy subjects.

Aim: To evaluate the association between OPG level and arterial stiffness parameters in patients with PAD and in healthy subjects.

Materials and methods: We studied 59 males with PAD (age 63±7 years) and 44 healthy subjects (age 54±7 years). Serum OPG level was measured using ELISA kit. Arterial stiffness parameters, such as aortic pulse wave velocity aPWV and augmentation index, were determined by applanation tonometry using the Sphygmocor device.

Results: OPG level (5.40±1.77 vs 4.19±1.14 (pmol/L); p<0.001) and aPWV (9.86±2.31 vs 7.69±1.66 (m/s); p<0.001) were different for the patients and for the controls. There was linear relationship between OPG level and aPWV in patients with PAD (R=0.51, p=0.0001) as well as in healthy individuals (R=0.47; p=0.002). In multiple regression models, OPG level was independently associated with aPWV along with age and mean arterial pressure in the patient group (R²=0.34; p=0.034) as well as in the controls (R²=0.49; p=0.037)

Conclusion: The independent association between OPG level and aPWV in patients with PAD and in controls suggests that calcification inhibitor OPG may be important in the process of aortic stiffening in atherosclerosis and in healthy subjects.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 3 - 4
Pages: 154 - 154
Publication Date: 2009/12/03
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2009.10.157 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - M. Zagura
AU  - M. Sergejev
AU  - J. Lieberg
AU  - P. Kampus
AU  - A. Peetsalu
AU  - J. Eha
AU  - M. Zilmer
AU  - J. Kals
PY  - 2009
DA  - 2009/12/03
TI  - 3.6 OSTEOPROTEGERIN IS ASSOCIATED INDEPENDENTLY WITH AORTIC STIFFNESS IN PATIENTS WITH ATHEROSCLEROSIS AND IN HEALTHY SUBJECTS
JO  - Artery Research
SP  - 154
EP  - 154
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.157
DO  - 10.1016/j.artres.2009.10.157
ID  - Zagura2009
ER  -

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