P1.06 THE ACCURACY OF CENTRAL SYSTOLIC BLOOD PRESSURE DETERMINED FROM THE SECOND SYSTOLIC PEAK OF THE PERIPHERAL PRESSURE WAVEFORM

S.S. Hickson; M. Butlin; F. Mir; J. Graggaber; J. Cheriyan; M. Yasmin; J.R. Cockcroft; I.B. Wilkinson; C.M. McEniery

doi:10.1016/j.artres.2009.10.009

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Volume 3, Issue 4, December 2009, Pages 162 - 162

P1.06 THE ACCURACY OF CENTRAL SYSTOLIC BLOOD PRESSURE DETERMINED FROM THE SECOND SYSTOLIC PEAK OF THE PERIPHERAL PRESSURE WAVEFORM

Authors

S.S. Hickson^a, M. Butlin^b, F. Mir^a, J. Graggaber^a, J. Cheriyan^a, M. Yasmin^a, J.R. Cockcroft^c, I.B. Wilkinson^a, C.M. McEniery^a

^aUniversity of Cambridge, Cambrige, United Kingdom

^bMacquarie University, Sydney, Australia

^cCardiff University, Cardiff, United Kingdom

Available Online 3 December 2009.

DOI: 10.1016/j.artres.2009.10.009 How to use a DOI?
Abstract: Central blood pressure may be a better predictor of cardiovascular risk than peripheral blood pressure. The central systolic blood pressure (cSBP) can be estimated from the late systolic shoulder of the radial pulse waveform (pSBP₂). We compared pSBP₂ with cSBP derived by a generalized transfer function in a large cohort of subjects, across a wide age-range. We also compared pSBP₂ with true central SBP (cSBPi) measured by cardiac catheterization.

Non-invasive measurements were made by applanation tonometry using the SphygmoCor device. The aortic pressure waveform was derived from the radial waveform using a validated transfer function. cSBPi measurements were carried out in 38 subjects undergoing diagnostic cardiac angiography, and the radial artery pressure waveform was recorded simultaneously using the SphygmoCor device.

Data from 1,880 subjects aged 18–85 years, yielded 10,269 individual observations. There was a strong correlation (r=0.99,P<0.001) and good agreement between pSBP₂ and the derived cSBP (mean difference=1±4mmHg). However, at lower average values of cSBP and pSBP₂, there was a greater difference between these two variables suggesting bias in the data. There was also a strong correlation and good agreement between cSBPi and pSBP₂ (r=0.96,P<0.001,mean difference=3±4mmHg), and between the derived cSBP and cSBPi (r=0.74,P<0.001,mean difference= −3±8mmHg).

pSBP₂ approximates cSBP in a large cohort, across a wide age-range, but this may be inaccurate at low systolic blood pressures. The reason for this bias has not yet been established, and further investigations are required. Until this is resolved, pSBP₂ should be used with caution, particularly in individuals with lower systolic blood pressures.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 3 - 4
Pages: 162 - 162
Publication Date: 2009/12/03
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2009.10.009 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - S.S. Hickson
AU  - M. Butlin
AU  - F. Mir
AU  - J. Graggaber
AU  - J. Cheriyan
AU  - M. Yasmin
AU  - J.R. Cockcroft
AU  - I.B. Wilkinson
AU  - C.M. McEniery
PY  - 2009
DA  - 2009/12/03
TI  - P1.06 THE ACCURACY OF CENTRAL SYSTOLIC BLOOD PRESSURE DETERMINED FROM THE SECOND SYSTOLIC PEAK OF THE PERIPHERAL PRESSURE WAVEFORM
JO  - Artery Research
SP  - 162
EP  - 162
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.009
DO  - 10.1016/j.artres.2009.10.009
ID  - Hickson2009
ER  -

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