P1.11 CAROTID STIFFNESS AND BAROREFLEX SENSITIVITY: THE EPP3 STUDY

DOI

10.1016/j.artres.2009.10.014How to use a DOI?

Abstract

Arterial baroreflex sensitivity (BS) is dependent on distension rate of baroreceptors, itself dependent on arterial stiffness. Differences in BS between younger and older subjects, and normotensive and hypertensive patients may be explained by differences in arterial stiffness. The objective was to demonstrate that increased carotid stiffness is a determinant of reduced baroreflex sensitivity.

Methods: 312 subjects were randomly selected from the EPP3 study (10000), a general population based cohort. We obtained intima-media thickness, internal-diameter and distensibility of the common carotid artery thanks to the Artlab ® echotracking device. Cross spectral analysis between distension rate and RR interval on 5min recordings was used for BS, estimated through the gain in the low frequency range (LF).

	Sympathetic activation (LF distension rate)	Baroreflex sensitivity (LF gain)
IMT	R2=0.01, p<0.05	R2=0.02, p<0.05
Dint	R2=0.01, p=0.06	R2=0.04, p<0.001
Distensibility	R2=0.08, p<0.001	R2=0.04, p<0.05
ACEi /ARB	R2=0.04, p<0.001	R2=0.02, p<0.05

Thicker, stiffer and larger carotid, an internal diameter were associated with older age, hypertensive status and increased markers of sympathetic tone and decrease BS, independently of age and blood pressure. Utilization of converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB) decreased sympathetic activation and increased baroreflex sensitivity. All these associations persist in multivariate analysis, independent of age and blood pressure.

Conclusion: baroreflex sensitivity estimated by the cross spectral analysis between the distension rate and the RR interval is correlated with carotid stiffness, thickening and dilatation of the common carotid artery. Antihypertensive drugs have differential effects on BS, ACEi or ARB sensitizing it.

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TY  - JOUR
AU  - A. Boudard
AU  - D. Laude
AU  - J.P. Empana
AU  - B. Pannier
AU  - K.T. Ong
AU  - F. Thomas
AU  - J. Perruca
AU  - X. Jouven
AU  - S. Laurent
AU  - P. Boutouryie
PY  - 2009
DA  - 2009/12/03
TI  - P1.11 CAROTID STIFFNESS AND BAROREFLEX SENSITIVITY: THE EPP3 STUDY
JO  - Artery Research
SP  - 163
EP  - 163
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.014
DO  - 10.1016/j.artres.2009.10.014
ID  - Boudard2009
ER  -