Artery Research

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Volume 3, Issue 4, December 2009, Pages 175 - 176

P5.09 LIGHT EXERCISE CENTRAL SYSTOLIC LOADING IS INCREASED IN PATIENTS WITH CYSTIC FIBROSIS RELATED DIABETES

Authors
J.H. Hull1, L. Ansley4, C.E. Bolton2, J.E. Sharman5, R.K. Knight3, D.J. Shale2, J.R. Cockcroft2, R. Garrod1
1St George’s, London, United Kingdom
2Cardiff University, Cardiff, United Kingdom
3Frimley Park Hospital, Surrey, United Kingdom
4University of Northumbria, Newcastle, United Kingdom
5University of Tasmania, Tasmania, Australia
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.064How to use a DOI?
Abstract

Background: As survival in the common autosomal recessive condition Cystic Fibrosis (CF) improves, there is focus on extra-pulmonary complications. Patients with CF have increased augmentation index (AIx) at rest which is greatest in those with diabetes (CFRD). We evaluated haemodynamic response to exercise, at an intensity similar to daily life.

Methods: We studied 36 (25 male) adults (n=11, CFRD) with stable CF, mean (range) age 28.9 (16–47) yrs and 25 age/gender/BMI matched controls. Central haemodynamic parameters; BP, AIx, augmented pressure (AP) and wasted LV pressure energy (▵EW) were determined by tonometry (SphygmoCor) at rest and 8minutes into a 10minute period of cycle ergometry at 60% age-predicted maximal HR. Serum IL-6 was measured.

Results: At rest, AIx was greater in both CFRD and non-CFRD patients than controls. During exercise, CFRD patients had greater MAP, AP, and ▵EW (p<0.05 for all) and a trend for greater AIx, whilst in non-CFRD patients were not different to controls (Table: at 8minutes exercise). Log10IL-6 was increased in patients (p<0.005) and related to exercise ▵EW (r=0.27, p<0.05).

Controls Non-CFRD CFRD
MAP (mmHg) 100 (8) 102 (11) 109 (11)*
AP (mmHg) −2.2 (4.7) −0.4 (4.6) 2.2 (4.2)*
▵EW (dynes.s/cm2) −576 (1400) −22.9 (1360) 665 (1164)*
AIx (%) −5.7 (11.2) −2.0 (10.9) 3.5 (10.3)

Mean (SD).

*

P<0.05 from controls (ANOVA).

Conclusions: Patients with CFRD have increased central systolic loading during exercise. These changes have implications for myocardial work and oxygen demand. In contrast, the haemodynamic response in non-CFRD patients does not appear to be maladapted.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
3 - 4
Pages
175 - 176
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.064How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - J.H. Hull
AU  - L. Ansley
AU  - C.E. Bolton
AU  - J.E. Sharman
AU  - R.K. Knight
AU  - D.J. Shale
AU  - J.R. Cockcroft
AU  - R. Garrod
PY  - 2009
DA  - 2009/12/03
TI  - P5.09 LIGHT EXERCISE CENTRAL SYSTOLIC LOADING IS INCREASED IN PATIENTS WITH CYSTIC FIBROSIS RELATED DIABETES
JO  - Artery Research
SP  - 175
EP  - 176
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.064
DO  - 10.1016/j.artres.2009.10.064
ID  - Hull2009
ER  -