P5.08 INDICES OF EARLY ATHEROSCLEROSIS AND ARTERIAL STIFFNESS AND CEREBRAL BLOOD FLOW VELOCITY

DOI

10.1016/j.artres.2009.10.063How to use a DOI?

Abstract

Objective: The aim of the study was to asses the relationship between structural (IMT- intima-media thickness) and functional (PWV - pulse wave velocity, SBP - systolic blood pressure, PP - pulse pressure) parameters of the large arterial damage and the mean blood flow velocity (CBFV) in middle cerebral artery (MCA).

Design and Methods: CBFV in (MCA) was measured bilaterally with transcranial Doppler (TCD). The early stage of vascular atherosclerosis was estimated with sonographic measurement of carotid IMT. We assessed large arterial stiffness using carotid-to-femoral PWV, brachial PP and SBP.

Results: The mean (SD) age of 165 analyzed subjects was 56.1 (11.8), age range: 22–86 years. We assessed the CBFV in thirds of respective distributions of IMT, PWV, PP and SBP and found that CBFV was less with advancing thirds of PWV and IMT (all p<0.02) but no such relation with PP and SBP (all p>0.37).

The within-tertile mean values and standard deviations are shown in table.

	Mean±SD value of characteristic
	I	II	III
SBP (mmHg)	116.3±5.9	134.3±4.8	159.2±13.1
PP (mmHg)	36.4±5.0	49.2±1.9	65.5±9.3
PWV (m/s)	9.8±1.2	12.2±0.57	16.2±3.0
IMT (mm)	0.6±0.08	0.9±0.06	1.2±0.2

Conclusion: Damage of large arteries expressed by increased IMT and PWV influences negatively the blood flow velocity in middle cerebral artery.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - A. Kwater
AU  - J. Gąsowski
AU  - T. Grodzicki
PY  - 2009
DA  - 2009/12/03
TI  - P5.08 INDICES OF EARLY ATHEROSCLEROSIS AND ARTERIAL STIFFNESS AND CEREBRAL BLOOD FLOW VELOCITY
JO  - Artery Research
SP  - 175
EP  - 175
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.063
DO  - 10.1016/j.artres.2009.10.063
ID  - Kwater2009
ER  -