P4.02 EFFECTS OF TOCOLYTICAL MEDICATION ON BLOOD PRESSURE AND BLOOD PRESSURE AMPLIFICATION

DOI

10.1016/j.artres.2009.10.043How to use a DOI?

Abstract

Objective: Atosiban (oxytocin-antagonist) and ritodrine (β-agonist) are frequently used tocolytics. Only a few studies investigated the hemodynamic effects of atosiban. We therefore aimed to study the effects on the blood pressure (BP) and BP-amplification.

Methods: Twenty healthy female volunteers (19–41 yrs) were given atosiban (300 μg/min over 2h) and placebo intravenously (IV) in a random crossover design. Eight of them also received ritodrine IV in escalating doses up to 400μg/min over 2h. The brachial artery (BA) blood pressures (BP) were taken by an oscillometric device (OMRON 705-IT) and the BP at the common carotid artery (CCA) and the radial artery (RA) were calculated using applanation tonometry. This was done at the steady state of the highest dose. Statistical analysis was done using Friedman and Wilcoxon test setting value of significance at 0.05.

Results: Effects on atosiban/placebo on N=20 did not differ from N=8.

Parameters (mmHg)	Ritodrine (n=8)	Atosiban (n=8)	Placebo (n=8)	p-value$
SBPCCA	113±13*#	105±10	100±6	0.012
SBPBA	114±13*#	106±10	103±6	0.004
SBPRA	115±15*#	110±13	110±7	0.368
DBPBA	55±11*#	69±6	68±5	0.008
MAP	76±10*#	84±8	82±6	<0.001

SBP (systolic BP), DBP (diastolic BP), MAP (mean arterial pressure).

$

Friedman-test;

*

significant vs. atosiban,

#

significant vs. placebo.

Conclusion: The data show increased SBP at the CCA and BA and lower DBP and MAP under ritodrine. The effects of atosiban did not differ from placebo. Although not statistically significant, the data suggest a nearly absent pressure amplification between CCA-RA during ritodrine administration.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - I.G.M. Fabry
AU  - P. De Paepe
AU  - L. Van Bortel
PY  - 2009
DA  - 2009/12/03
TI  - P4.02 EFFECTS OF TOCOLYTICAL MEDICATION ON BLOOD PRESSURE AND BLOOD PRESSURE AMPLIFICATION
JO  - Artery Research
SP  - 170
EP  - 170
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.043
DO  - 10.1016/j.artres.2009.10.043
ID  - Fabry2009
ER  -