Artery Research

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Volume 3, Issue 4, December 2009, Pages 170 - 171

P4.03 SUB-ACUTE EFFECTS OF BLOOD PRESSURE LOWERING WITH AMLODIPINE OR LISINOPRIL ON LOCAL CAROTID ARTERY HAEMODYNAMICS

Authors
B. Ariff1, F. Glor2, L. Crowe3, Y. Xu2, W. Vennart4, D. Firmin3, S. Thom1, A.D. Hughes1
1International Centre for Circulatory Health, National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, & Imperial College Healthcare NHS Trust, London, United Kingdom
2Department of Chemical Engineering, Faculty of Engineering, Imperial College London, London, United Kingdom
3Cardiovascular Magnetic Resonance Unit, Royal Brompton Hospital & National Heart and Lung Institute Division, Faculty of Medicine, Imperial College London, London, United Kingdom
4Pfizer Ltd, Global Research and Development, Sandwich Laboratories, Sandwich, Kent, United Kingdom
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.044How to use a DOI?
Abstract

Introduction: Anti-hypertensive agents differ in their ability to slow progression of the increase in carotid artery intima-media thickness (IMT) with disease and have different effects on the lumen diameter (LD) of the carotid artery. We hypothesised that changes in flow and shear stress in the common carotid artery may contribute to these differences in remodelling.

Methods: 10 treatment naïve hypertensive subjects were recruited into a double blind, placebo controlled, randomised 3-way cross-over study comparing the effects of 7 days treatment with amlodipine or lisinopril. Brachial and carotid blood pressure (BP), common carotid artery (CCA) flow rate, IMT and LD were measured at the end of each treatment period. Magnetic resonance imaging-based computational fluid dynamics was used to calculate time averaged wall shear stress (WSS) in the carotid artery bifurcation.

There were significant reductions in brachial and carotid BP with both active treatments compared to placebo, but brachial and carotid BP did not differ significantly between the antihypertensive agents. CCA flow rate was significantly lower and distal vascular resistance was higher following lisinopril treatment compared with amlodipine. WSS on the inner wall of the CCA was significantly lower after lisinopril treatment compared with amlodipine.

Conclusion: Amlodipine causes increased carotid blood flow and increased WSS compared with lisinopril, probably as a result of greater cerebrovascular vasodilatation. These effects could account for differences in arterial remodelling caused by these agents.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
3 - 4
Pages
170 - 171
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.044How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - B. Ariff
AU  - F. Glor
AU  - L. Crowe
AU  - Y. Xu
AU  - W. Vennart
AU  - D. Firmin
AU  - S. Thom
AU  - A.D. Hughes
PY  - 2009
DA  - 2009/12/03
TI  - P4.03 SUB-ACUTE EFFECTS OF BLOOD PRESSURE LOWERING WITH AMLODIPINE OR LISINOPRIL ON LOCAL CAROTID ARTERY HAEMODYNAMICS
JO  - Artery Research
SP  - 170
EP  - 171
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.044
DO  - 10.1016/j.artres.2009.10.044
ID  - Ariff2009
ER  -