P7.11 HIGH ANKLE-BRACHIAL INDEX IS ASSOCIATED WITH INCREASED AORTIC PULSE WAVE VELOCITY: THE CZECH POST-MONICA STUDY

P. Wohlfahrt; M. Ingrischová; D. Palouš; A. Krajcoviechová; J. Seidlerová; M. Dolejšová; M. Galovcová; J. Bruthans; V. Adámková; M. Jozífová; J. Filipovský; R. Cífková

doi:10.1016/j.artres.2009.10.104

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Volume 3, Issue 4, December 2009, Pages 186 - 186

P7.11 HIGH ANKLE-BRACHIAL INDEX IS ASSOCIATED WITH INCREASED AORTIC PULSE WAVE VELOCITY: THE CZECH POST-MONICA STUDY

Authors

P. Wohlfahrt¹, M. Ingrischová², D. Palouš¹, A. Krajcoviechová¹, J. Seidlerová³, M. Dolejšová³, M. Galovcová¹, J. Bruthans¹, V. Adámková¹, M. Jozífová¹, J. Filipovský³, R. Cífková¹

¹Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

²2nd Medical Department-Clinical Department of Cardiology and Angiology, 1st Medical Faculty, Charles University, Prague, Czech Republic

³Center of Preventive Cardiology, 2nd Department of Internal Medicine, Charles University, Medical Faculty, Pilsen, Prague, Czech Republic

Available Online 3 December 2009.

DOI: 10.1016/j.artres.2009.10.104 How to use a DOI?
Abstract: Ankle brachial index (ABI) has increasingly been used in general practice to identify patients with low ABI at high cardiovascular risk. However there is no consensus on the clinical significance of high ABI. The aim of our study was to compare large artery stiffness as a marker of cardiovascular risk in patients with low (<1.0), normal (1.0–1.4) and high ABI (>1.4).

Methods: 911 patients from the Czech post-MONICA study (a randomly selected 1% representative population sample, mean age 54±13.5 years, 47% of men) were examined. ABI was measured using a handheld Doppler and aortic pulse wave velocity (aPWV) using the Sphygmocor device.

Results: Of 911 patients, 28 (3.1%) had low ABI and 23 (2.5%) high ABI. There was a U-shaped association between aPWV and ABI. aPWV was significantly higher in patients with low and high ABI compared with normal ABI group (11.1±2.8, 8.3±2.3, p<0.001; 10.8±2.5, 8.3±2.3, p<0.001) and it did not differ between patients with high and low ABI (11.1±2.8, 10.8±2.5, p=0.86). In the stepwise multiple regression analysis low and high ABI were independent predictors of increased aPWV together with age, central systolic blood pressure, heart rate, BMI and hypertension.

Conclusion: This is the first study showing increased aortic PWV in patients with high ABI pointing to increased cardiovascular risk in this group.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 3 - 4
Pages: 186 - 186
Publication Date: 2009/12/03
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2009.10.104 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - P. Wohlfahrt
AU  - M. Ingrischová
AU  - D. Palouš
AU  - A. Krajcoviechová
AU  - J. Seidlerová
AU  - M. Dolejšová
AU  - M. Galovcová
AU  - J. Bruthans
AU  - V. Adámková
AU  - M. Jozífová
AU  - J. Filipovský
AU  - R. Cífková
PY  - 2009
DA  - 2009/12/03
TI  - P7.11 HIGH ANKLE-BRACHIAL INDEX IS ASSOCIATED WITH INCREASED AORTIC PULSE WAVE VELOCITY: THE CZECH POST-MONICA STUDY
JO  - Artery Research
SP  - 186
EP  - 186
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.104
DO  - 10.1016/j.artres.2009.10.104
ID  - Wohlfahrt2009
ER  -

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