Artery Research

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Volume 3, Issue 4, December 2009, Pages 184 - 184

P7.04 PROGRESSIVE ARTERIAL STIFFENING IN RENAL TRANSPLANT RECIPIENTS – RESULTS OF 28-MONTH FOLLOW-UP

Authors
P. Strózecki1, A. Adamowicz2, M. Kozlowski1, Z. Wlodarczyk2, J. Manitius1
1Dept of Nephrology, Hypertension and Internal Disease, Bydgoszcz, Poland
2Dept of Transplantology and Surgery, Bydgoszcz, Poland
Available Online 3 December 2009.
DOI
10.1016/j.artres.2009.10.097How to use a DOI?
Abstract

Recent follow-up studies showed no change or even short-term improvement of arterial stiffness after kidney transplantation. Data from general population and end-stage renal disease patients suggest, that PWV increases with age of 0,07–0,08m/s for each year of life. It was shown recently that reduced glomerular filtration rate (GFR) is associated with increased arterial stiffness in RTR. We investigated the change of PWV during follow-up and its relationship with graft function. Carotid-femoral PWV was measured at baseline (PWV1) and after 28±3 (range 24–34) months of follow-up (PWV2) in 61 RTR aged 49±12 years. Fasting blood was collected for serum creatinine, calcium (Ca), phosphorus (P), and high-sensitive C-reactive protein (hsCRP). GFR was calculated with MDRD formula (eGFR). ΔPWV was calculated as (PWV2-PWV1)/PWV1. Clinical and laboratory data were analysed to identify factors associated with ΔPWV. Results are shown as mean±SD.

Baseline Follow-up P
PWV (m/s) 9,1±1,7 9,8±2,0 < 0,002
Body mass (kg) 73,7±13,9 75,4±13,6 < 0,001
SBP (mmHg) 132±17 137±19 =0,05
DBP (mmHg) 83±11 84±10 NS
MAP (mmHg) 99±12 102±12 NS
PP (mmHg) 50±11 53±14 <0,05
eGFR (ml/min/1,73m2) 55±16 56±16 NS

Serum Ca, P, Ca × P product, hsCRP did not change during follow-up. Significant positive correlation was found between ΔPWV and serum phosphorus (r=0,27; p<0,05) and Ca × P product (r=0,25; p<0,05) but not with body mass, BMI, SBP, DBP, MAP, PP, Ca, eGFR, hsCRP.

Arterial stiffness increased in renal transplant recipients despite stable graft function. Phosporus matebolism disturbances might be involved in arterial stiffening in RTR.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
3 - 4
Pages
184 - 184
Publication Date
2009/12/03
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2009.10.097How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - P. Strózecki
AU  - A. Adamowicz
AU  - M. Kozlowski
AU  - Z. Wlodarczyk
AU  - J. Manitius
PY  - 2009
DA  - 2009/12/03
TI  - P7.04 PROGRESSIVE ARTERIAL STIFFENING IN RENAL TRANSPLANT RECIPIENTS – RESULTS OF 28-MONTH FOLLOW-UP
JO  - Artery Research
SP  - 184
EP  - 184
VL  - 3
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.10.097
DO  - 10.1016/j.artres.2009.10.097
ID  - Strózecki2009
ER  -