Artery Research

<Previous Article In Issue
Next Article In Issue>
Volume 24, Issue C, December 2018, Pages 32 - 39

Association of serum paraoxonase activity with lipid profile, APO-A and APO-B in subjects with different levels of HDL

Authors
Maryam Teimouri, Hashem Nayeri*
Department of Biochemistry, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
*Corresponding author. E-mail address: hnaieri@gmail.com (H. Nayeri).
Corresponding Author
Hashem Nayeri
Received 15 September 2018, Revised 15 October 2018, Accepted 22 October 2018, Available Online 9 November 2018.
DOI
10.1016/j.artres.2018.10.227How to use a DOI?
Keywords
High-density lipoprotein; Coronary heart disease; Paraoxonase-1; Lipoproteins; ApoA; ApoB
Abstract

Background: Coronary heart diseases are inversely related to plasma high-density lipoprotein (HDL) level. Paraoxonase-1 (PON1) is mainly associated with HDL and plays a vital role in protection of low-density lipoprotein (LDL) and HDL. The aim of this study was to investigate the association between paraoxonase activity (PON1) with lipid profile, apoA-І, apoB and apoB/apoA-І ratio in subjects with different level of HDL cholesterol (HDL-C).

Methods: 135 subjects, 20–60 years old, contributed to this study. The subjects were divided into three groups (45 in each group) with different levels of HDL-C (High, Normal and Low). For each group, the activity of PON1 was measured using paraoxon as a substrate. Moreover, the serum level of lipid profile, ApoA and apoB were measured. The statistical analysis was performed using SPSS software.

Results: PON-1 activity and apoA-І level were decreased in subjects with lower level of HDL-C (P < 0.001). ApoB and apoB/apoA-І ratio were higher in subjects with lower level of HDL-C (P < 0.001). Serum PON-1 activity was positively correlated with TC, TG, apo A-B, and LDL-C levels (P < 0.01).

Conclusions: In conclusion, determination of serum PON1 activity and lipoproteins may play important role in earlier prediction of CAD and help to design a therapeutic for treatment of CAD toward PON1 activity regulation.

Copyright
© 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
24 - C
Pages
32 - 39
Publication Date
2018/11/09
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.10.227How to use a DOI?
Copyright
© 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Maryam Teimouri
AU  - Hashem Nayeri
PY  - 2018
DA  - 2018/11/09
TI  - Association of serum paraoxonase activity with lipid profile, APO-A and APO-B in subjects with different levels of HDL
JO  - Artery Research
SP  - 32
EP  - 39
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.10.227
DO  - 10.1016/j.artres.2018.10.227
ID  - Teimouri2018
ER  -