Artery Research

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Volume 24, Issue C, December 2018, Pages 40 - 46

Relationships between blood pressure variability and silent cerebral infarction in patients with primary hypertension

Authors
Xianglin Chia, 1, Xingyao Wangb, 1, Zhaorong Guoa, Honghao Mana, *, Hongxiao Xuc, **, Yingcui Wangc, Chengyu Liub, ***
aDepartment of Neurology, Weihai Central Hospital Affiliated to Qingdao University, Weihai, 264400, China
bSchool of Instrument Science and Engineering, Southeast University, Nanjing, 210096, China
cDepartment of Cardiology, Shandong University Qilu Hospital, Qingdao, 266035, China
1

These authors contribute equally for this paper.

*Corresponding author. E-mail address: manhonghao1@163.com (H. Man)
**Corresponding author. E-mail address: rilla@163.com (H. Xu)
***Corresponding author. E-mail address: chengyu@seu.edu.cn (C. Liu).
Corresponding Authors
Honghao Man, Hongxiao Xu, Chengyu Liu
Received 27 September 2018, Revised 31 October 2018, Accepted 5 November 2018, Available Online 16 November 2018.
DOI
10.1016/j.artres.2018.11.001How to use a DOI?
Keywords
Primary hypertension; Blood pressure variability; Silent cerebral infarction
Abstract

Aims: This study aimed to investigate the relationship between blood pressure variability and the incidence of silent cerebral infarction (SCI) in patients with primary hypertension.

Methods: The 346 hospitalized patients with primary hypertension were divided into primary hypertension group (160 cases) and primary hypertension combined with SCI group (186 cases). The 24-h ambulatory blood pressure was measured. Clinical data were collected. Univariate and multivariate logistic regression analysis was performed.

Results: There were significant differences between patients with primary hypertension combined with SCI and patients with primary hypertension only in age, stroke history, diabetes history, smoking, alcohol consumption, FBG, Hcy, and Lp-PLA2. The 24-h ambulatory blood pressure monitoring results suggested that dSBP, dSSD, 24hSBP, nSSD, dDBP, dDSD, nDSD, 24hDSD, ddnSBP, and ddnDBP in patients with hypertension and SCI were higher than those in patients with primary hypertension only. Non-dipper blood pressure was more common. Multivariate logistic regression analysis showed dSSD (OR: 1.374, 95%CI [1.173–1.609]), 24 h DSD (OR: 1.194, 95%CI [1.017,1.402]), dSBP (OR: 1.062, 95%CI [1.022, 1.103]), age (OR: 1.042, 95%CI [1.005, 1.080]), smoking (OR: 2.610, 95%CI [1.495, 4.556]), fasting plasma glucose (OR: 1.183, 95%CI [1.040, 1.345]), and Lp-PLA2 (OR: 1.004, 95%CI [1.003, 1.006]) were positively correlated with SCI in hypertension patients.

Conclusions: Blood pressure variability (dSSD and24hDSD) is independently associated with SCI in patients with primary hypertension. In addition, traditional risk factors, blood pressure level (dSBP), age, smoking, fasting plasma glucose, and Lp-PLA2 were also independently associated with SCI in patients with primary hypertension.

Copyright
© 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
24 - C
Pages
40 - 46
Publication Date
2018/11/16
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2018.11.001How to use a DOI?
Copyright
© 2018 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Xianglin Chi
AU  - Xingyao Wang
AU  - Zhaorong Guo
AU  - Honghao Man
AU  - Hongxiao Xu
AU  - Yingcui Wang
AU  - Chengyu Liu
PY  - 2018
DA  - 2018/11/16
TI  - Relationships between blood pressure variability and silent cerebral infarction in patients with primary hypertension
JO  - Artery Research
SP  - 40
EP  - 46
VL  - 24
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2018.11.001
DO  - 10.1016/j.artres.2018.11.001
ID  - Chi2018
ER  -