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Volume 1, Issue 4, August 2020, Pages 279 - 287

Effects of Dietary Interventions on Gut Microbiota in Humans and the Possible Impacts of Foods on Patients’ Responses to Cancer Immunotherapy

Authors
Li-Shu Wang1, *, Yue Yang Mo1, Yi-Wen Huang2, Carla Elena Echeveste1, Hsin-Tzu Wang1, Jiali Chen3, Kiyoko Oshima4, Martha Yearsley5, Jesus Simal-Gandaraf6, Maurizio Battino6, 7, 8, Jianbo Xiao9, Jiebiao Chen10, Chongde Sun10, Jianhua Yu11, Weibin Bai3, *
1Division of Hematology and Oncology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA
2Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, WI, USA
3Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection, Jinan University, Guangzhou, China
4Department of Pathology, Johns Hopkins University, MD, USA
5Department of Pathology, The Ohio State University, OH, USA
6Department of Analytical Chemistry and Food Science, Faculty of Food Science and Technology, University of Vigo, Spain
7International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, China
8Department of Odontostomatologic and Specialized Clinical Sciences, Faculty of Medicine, Polytechnic University of Marche, Ancona, Italy
9Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Taipa, Macau, China
10Laboratory of Fruit Quality Biology/Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology/The State Agriculture Ministry Laboratory of Horticultural Plant Growth, Development and Quality Improvement, Zhejiang University, Zijingang Campus, Hangzhou, China
11Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center and Beckman Research Institute, CA, USA
*Corresponding authors. Email: liswang@mcw.edu; baiweibin@163.com
Corresponding Authors
Li-Shu Wang, Weibin Bai
Received 5 June 2020, Accepted 21 August 2020, Available Online 27 August 2020.
DOI
10.2991/efood.k.200824.002How to use a DOI?
Keywords
Fruits and vegetables; whole grains; gut microbiota; cancer immunotherapy; human clinical trials
Abstract

The gut microbiota—the community of microorganisms in the gut—has been implicated in many physical and mental disorders in addition to intestinal diseases. Diets are the most studied and promising factors for altering it. Indeed, certain dietary interventions that increase fiber intake rapidly change levels of certain nutrients that can modify the composition of the microbiota, promoting richness and diversity. Recent intriguing evidence from several human clinical trials suggested that the composition and diversity of patients’ gut microbiotas at baseline can influence their responses to cancer immunotherapy. If the factors that influence the gut microbiota were fully understood, it is conceivable that manipulating them could boost therapeutic responses in cancer patients. In this review, we investigate the possibility of using fruits, vegetables, or whole grains to enhance response to cancer therapies in humans, as current evidence suggests that these dietary components can manipulate and enhance diversity of the gut microbiota. Accordingly, dietary interventions with locally available fruits, vegetables, and whole grains might be an affordable and safe approach to enhancing the diversity of the gut microbiota before immunotherapy, in turn improving patients’ responses to their treatments.

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Copyright
© 2020 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Next Article In Issue>
Journal
eFood
Volume-Issue
1 - 4
Pages
279 - 287
Publication Date
2020/08/27
ISSN (Online)
2666-3066
DOI
10.2991/efood.k.200824.002How to use a DOI?
Copyright
© 2020 International Association of Dietetic Nutrition and Safety. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Li-Shu Wang
AU  - Yue Yang Mo
AU  - Yi-Wen Huang
AU  - Carla Elena Echeveste
AU  - Hsin-Tzu Wang
AU  - Jiali Chen
AU  - Kiyoko Oshima
AU  - Martha Yearsley
AU  - Jesus Simal-Gandaraf
AU  - Maurizio Battino
AU  - Jianbo Xiao
AU  - Jiebiao Chen
AU  - Chongde Sun
AU  - Jianhua Yu
AU  - Weibin Bai
PY  - 2020
DA  - 2020/08/27
TI  - Effects of Dietary Interventions on Gut Microbiota in Humans and the Possible Impacts of Foods on Patients’ Responses to Cancer Immunotherapy
JO  - eFood
SP  - 279
EP  - 287
VL  - 1
IS  - 4
SN  - 2666-3066
UR  - https://doi.org/10.2991/efood.k.200824.002
DO  - 10.2991/efood.k.200824.002
ID  - Wang2020
ER  -