Glucose-6-phosphate Dehydrogenase Deficiency in Patients Attending Tertiary Care Health Setting in Peshawar

Authors

Zair Hassan¹, Iftikhar Ali², Faheemullah Khan^{3, *,} , Muhammad Shahbaz Khan¹

¹Department of Cardiology, Lady Reading Hospital, Peshawar, Pakistan

²Pharmacy Unit, Paraplegic Center, Hayatabad, Peshawar, Pakistan

³Department of Diagnostic Radiology, Aga Khan University Hospital, Karachi, Pakistan

^*Corresponding author. Email: islamianfellow@hotmail.com

DOI

10.2991/dsahmj.k.200613.001How to use a DOI?

Keywords

Deficiency; G6PD; hemolysis; Pathans; red blood cells

Abstract

Glucose-6-phosphate Dehydrogenase (G6PD) deficiency is an X-linked disorder that mainly affects red blood cells resulting in its lysis manifesting as hemolytic anemia. The purpose of this study is to measure the burden of this genetic disorder in patients presenting to a tertiary care health setting of Peshawar, Pakistan, in order to validate previous findings. The retrospective records of 1440 patients were retrieved from the Hospital Management and Information System for the period spanning from January 2017 to December 2018. The data of 1402 patients were included in the final analysis. The mean (standard deviation) age of the patients was 15.02 ± 15.50 (range, 0.50–91.50) years. Of the total, 78.1% were males and 21.9% were females. The frequency of G6PD deficiency recorded was 12.50%. The highest proportion was noted in age groups of <5 years (76; 43.4%) and 20–40 years (37; 21.1%). The frequency of the disorder in males and females was 13.79% and 7.82%, respectively. This study records the high burden of G6PD deficiency in Pathans which is comparable to those reported in the literature. G6PD deficiency is relatively more prevalent in this area. Screening and educational programs for G6PD deficiency are recommended in these high-risk areas irrespective of sex to prevent G6PD deficiency-related morbidity.

Copyright

© 2020 Dr. Sulaiman Al Habib Medical Group. Publishing services by Atlantis Press International B.V.

Open Access

This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - JOUR
AU  - Zair Hassan
AU  - Iftikhar Ali
AU  - Faheemullah Khan
AU  - Muhammad Shahbaz Khan
PY  - 2020
DA  - 2020/06/18
TI  - Glucose-6-phosphate Dehydrogenase Deficiency in Patients Attending Tertiary Care Health Setting in Peshawar
JO  - Dr. Sulaiman Al Habib Medical Journal
SP  - 72
EP  - 75
VL  - 2
IS  - 2
SN  - 2590-3349
UR  - https://doi.org/10.2991/dsahmj.k.200613.001
DO  - 10.2991/dsahmj.k.200613.001
ID  - Hassan2020
ER  -