Artery Research

<Previous Article In Issue
Next Article In Issue>
Volume 7, Issue 3-4, September 2013, Pages 148 - 149

P5.19 STIFF ARTERIES, STIFF HEARTS?

Authors
O. Mac Ananey, V. Maher
Tallaght Hospital, Dublin, Ireland
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.167How to use a DOI?
Abstract

Objectives: To examine the relationship between arterial stiffness and diastolic function in healthy normotensive subjects.

Methods: For this study, 43 male (40±10 years) and 64 female (40±9 years) subjects were recruited. All were lifelong non-smokers, normolipidaemic, normoglycaemic and had normal 24-hour blood pressure responses (SBP\DBP <140\90). For each subject, metabolic profile and anthropometric measurements were recorded. Carotid-femoral pulse wave velocity (PWV) was measured to assess arterial stiffness. Early/late mitral valve filling velocity (MV E/A) and isovolumetric relaxation time (IVRT) was used to assess diastolic function.

Results: The indices of diastolic function, LV IVRT & MV E/A ratio, and 24-hour ambulatory systolic & diastolic blood pressure were significantly correlated with PWV. In addition, age, anthropometric and metabolic values, such as waist/height ratio, fasting glucose (Glucose Fast), glycosylated haemoglobin (HbA1c) were also significantly correlated with PWV (Table 1). In a multiple regression analysis, age, 24-hour DBP, and MV E/A ratio remained independent predictors of PWV.

Univariate Correlation with PWV
n=107 r P
Age 0.45 <0.0001
BMI 0.18 0.06
Waist/Height 0.22 <0.05
GlucoseFast 0.22 <0.05
HbA1c 0.26 <0.01
24-hour SBP 0.28 <0.01
24-hour DBP 0.32 <0.001
LV IVRT 0.28 <0.01
MV E/A −0.44 <0.0001
Table 1

Spearman’s univariate correlation with PWV.

Conclusion: Left ventricular diastolic function is associated with arterial stiffness even in “healthy” normotensive subjects, suggesting, that changes in arterial and left ventricular walls occur in parallel.

Open Access
This is an open access article distributed under the CC BY-NC license.

Download article (PDF)
View full text (HTML)

<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
148 - 149
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.167How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - O. Mac Ananey
AU  - V. Maher
PY  - 2013
DA  - 2013/11/11
TI  - P5.19 STIFF ARTERIES, STIFF HEARTS?
JO  - Artery Research
SP  - 148
EP  - 149
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.167
DO  - 10.1016/j.artres.2013.10.167
ID  - MacAnaney2013
ER  -