Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 148 - 149

P5.19 STIFF ARTERIES, STIFF HEARTS?

Authors
O. Mac Ananey, V. Maher
Tallaght Hospital, Dublin, Ireland
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.167How to use a DOI?
Abstract

Objectives: To examine the relationship between arterial stiffness and diastolic function in healthy normotensive subjects.

Methods: For this study, 43 male (40±10 years) and 64 female (40±9 years) subjects were recruited. All were lifelong non-smokers, normolipidaemic, normoglycaemic and had normal 24-hour blood pressure responses (SBP\DBP <140\90). For each subject, metabolic profile and anthropometric measurements were recorded. Carotid-femoral pulse wave velocity (PWV) was measured to assess arterial stiffness. Early/late mitral valve filling velocity (MV E/A) and isovolumetric relaxation time (IVRT) was used to assess diastolic function.

Results: The indices of diastolic function, LV IVRT & MV E/A ratio, and 24-hour ambulatory systolic & diastolic blood pressure were significantly correlated with PWV. In addition, age, anthropometric and metabolic values, such as waist/height ratio, fasting glucose (Glucose Fast), glycosylated haemoglobin (HbA1c) were also significantly correlated with PWV (Table 1). In a multiple regression analysis, age, 24-hour DBP, and MV E/A ratio remained independent predictors of PWV.

Univariate Correlation with PWV
n=107 r P
Age 0.45 <0.0001
BMI 0.18 0.06
Waist/Height 0.22 <0.05
GlucoseFast 0.22 <0.05
HbA1c 0.26 <0.01
24-hour SBP 0.28 <0.01
24-hour DBP 0.32 <0.001
LV IVRT 0.28 <0.01
MV E/A −0.44 <0.0001
Table 1

Spearman’s univariate correlation with PWV.

Conclusion: Left ventricular diastolic function is associated with arterial stiffness even in “healthy” normotensive subjects, suggesting, that changes in arterial and left ventricular walls occur in parallel.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
148 - 149
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.167How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - O. Mac Ananey
AU  - V. Maher
PY  - 2013
DA  - 2013/11/11
TI  - P5.19 STIFF ARTERIES, STIFF HEARTS?
JO  - Artery Research
SP  - 148
EP  - 149
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.167
DO  - 10.1016/j.artres.2013.10.167
ID  - MacAnaney2013
ER  -