Artery Research

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Volume 7, Issue 3-4, September 2013, Pages 118 - 118

P1.30 DIFFERENTIAL MEANING OF RETINAL ARTERIAL REMODELING AND AORTIC DISTENSIBILITY IN YOUNG HYPERTENSIVES

Authors
D. Rosenbaum1, 2, A. Redheuil2, N. Kachenoura2, P. Cluzel2, A. Decesare2, E. Koch3, M. Paques3, X. Girerd1
1Pitié salpêtrière Hospital, Cardiovascular Prevention Unit, Paris, France
2Laboratoire d’imagerie fonctionnelle, UPMC INSERM U 678, Paris, France
3Institut de la vision, CIC des XV/XX, Paris, France
Available Online 11 November 2013.
DOI
10.1016/j.artres.2013.10.059How to use a DOI?
Abstract

Objectives: Microvascular arterial remodelling has been linked with target organ damage and cardiovascular events. Our objective was to link retinal arterial remodelling assessed using a new interferometry technique (adaptative optics, AO) and ascending aortic function and geometry.

Methods: 9 patients (median age 43, range 30 to 58, 60% male) with primary hypertension underwent AO to measure retinal arteries wall to lumen ratio (WLR) index and a cardiovascular magnetic resonance exam (1.5T Siemens) of the proximal aorta. Ascending aortic diameters and strain were calculated using the ARTFUN software and an automated segmentation of SSFP cine acquisitions acquired in the axial view, during breath-holding, at the level of pulmonary bifurcation perpendicular to the aorta. Aortic strain was used to calculate aortic distensibility in each subject: distensibility (AD) =strain/cPP where cPP is the central pulse pressure obtained by tonometry (sphygmocor®). Home Blood pressure (hBP) records were used to define BP levels

Results: Characteristics of the population are shown in table 1. In univariate analysis, retinal WLR was linked to systolic hBP (r= 0.53, p= 0,006) and weight (r= 0.38, p= 0,03) but not with any other risk factors. AD was linked to age (r= 0.53, p= 0,006), systolic hBP (r= 0.53, p= 0,006) and tobacco status. In multivariate analysis, the only significant determinants remaining were age for AD and systolic hBP for WLR.

Conclusion: In young hypertensives, AD and WLR are representative of 2 different arterial aging factors: age for AD and hypertension for WLR.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
7 - 3-4
Pages
118 - 118
Publication Date
2013/11/11
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2013.10.059How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - D. Rosenbaum
AU  - A. Redheuil
AU  - N. Kachenoura
AU  - P. Cluzel
AU  - A. Decesare
AU  - E. Koch
AU  - M. Paques
AU  - X. Girerd
PY  - 2013
DA  - 2013/11/11
TI  - P1.30 DIFFERENTIAL MEANING OF RETINAL ARTERIAL REMODELING AND AORTIC DISTENSIBILITY IN YOUNG HYPERTENSIVES
JO  - Artery Research
SP  - 118
EP  - 118
VL  - 7
IS  - 3-4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2013.10.059
DO  - 10.1016/j.artres.2013.10.059
ID  - Rosenbaum2013
ER  -